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A practical and alternative approach to access thioesters is presented, utilizing readily available starting precursors such as carboxylic acids and thiols direct reductive C-S cross-coupling reactions under palladium catalysis. The present protocol features good atom economy, excellent yields, wide functional group tolerance, broad substrate scope, operational simplicity, and mild reaction conditions with no additional steps.
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http://dx.doi.org/10.1039/d5ob00151j | DOI Listing |
JCO Precis Oncol
September 2025
Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, CA.
Purpose: mutations are classically seen in non-small cell lung cancers (NSCLCs), and EGFR-directed inhibitors have changed the therapeutic landscape in patients with -mutated NSCLC. The real-world prevalence of -mutated ovarian cancers has not been previously described. We aim to determine the prevalence of pathogenic or likely pathogenic mutations in ovarian cancer and describe a case of -mutated metastatic ovarian cancer with a durable response to osimertinib, an EGFR-directed targeted therapy.
View Article and Find Full Text PDFSci Adv
September 2025
Key Laboratory of Soybean Disease and Pest Control (Ministry of Agriculture and Rural Affairs), Key Laboratory of Plant Immunity, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Salicylic acid (SA) is a key defense hormone shaped by temperature. High temperatures suppress, while low temperatures enhance, SA biosynthesis and signaling, thereby influencing plant immunity and temperature resilience. This review synthesizes current understanding of how temperature modulates SA pathways and their cross-talk with other hormones to balance growth and defense.
View Article and Find Full Text PDFNeurochem Res
September 2025
Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Parkinson's disease (PD) is characterized by impairments in motor control following the degeneration of dopamine-producing neurons located in the substantia nigra pars compacta. Environmental pesticides such as Paraquat (PQ) and Maneb (MB) contribute to the onset of PD by inducing oxidative stress (OS). This study evaluated the therapeutic efficacy of moderate physical activity (PA) on both motor and non-motor symptoms in a Wistar rat model of Paraquat and Maneb (PQ/MB) induced PD.
View Article and Find Full Text PDFPlant Foods Hum Nutr
September 2025
Graduate School of Food and Nutritional Sciences, Toyo University, 48-1, Oka, 351-8501, Asaka, Saitama, Japan.
Pea shoots (Pisum sativum) are well known to have nutritional benefits when consumed raw; however, the effects of home cooking on their bioactive compounds remain unclear. Therefore, we investigated how different cooking methods affect the antioxidant activity and stability of antioxidants. Our evaluation revealed that antioxidant activity is preserved by steaming but significantly reduced by microwaving and boiling, which also causes weight loss during cooking.
View Article and Find Full Text PDFLung
September 2025
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Introduction: Lactate has emerged as a multifunctional signaling molecule regulating various physiological and pathological processes. Furthermore, lactylation, a newly identified posttranslational modification triggered by lactate accumulation, plays significant roles in human health and diseases. This study aims to investigate the roles of lactate/lactylation in respiratory diseases.
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