Identification of risk factors for renal progression in adults with IgAV: a retrospective cohort study of a single center in northwest China.

Objectives: This investigation sought to examine the clinical and pathological characteristics, outcomes, and risk factors linked to the progression of renal function in adult-onset immunoglobulin A (IgA) vasculitis within a single center in northwest China.

Methods: Data were retrospectively gathered from cases of adult-onset IgA vasculitis recorded at a tertiary hospital in northwest China, covering the period from January 2013 to August 2024. During the follow-up, clinical information was compared between patients who advanced to chronic kidney disease (CKD) stage 3 and those who did not.

Results: A sum of 1082 adult-onset IgA vasculitis patients (632 men; median age of 37 years) were included. Among patients with baseline proteinuria >0.5 g/24h (43.9%), 40.7% progressed to chronic kidney disease (CKD) stage 3, while 5.1% developed end-stage renal disease (ESRD). COX regression analysis indicated that older age, renal pathological grade IV, hypertension (HTN), diabetes, hyperlipidemia, and hyperuricemia were independent risk factors for CKD stage 3 progression in individuals with adult-onset IgA vasculitis.

Conclusions: Older age and comorbidities such as hypertension and diabetes significantly increase the risk of renal progression in adult-onset IgAV. Early management of these comorbidities may mitigate the risk of CKD progression.