Electrochemotherapy Intralesional Treatment in a Captive Peregrine Falcon () with Dermal Squamous Cell Carcinoma.

Captive birds of prey often exceed their wild counterparts' lifespan, as seen in bald eagles (, ~20 years wild vs. ~40 years captive), golden eagles (, ~32 years wild vs. ~46 years captive), and Andean condors (, ~50 years wild vs. ~79 years captive), highlighting the impact of controlled environments on longevity. However, recent evidence suggests a rising incidence of neoplastic processes in these species. While previous studies have indicated a higher-than-expected prevalence of neoplasia in raptors, comprehensive research on this topic remains scarce. Squamous cell carcinoma (SCC), a frequently reported neoplasm in pet birds, has been documented in birds of prey, though the literature on its prevalence and management is limited. Retrospective studies have identified SCC cases in peregrine falcons (), primarily affecting the flank or thigh, with locally invasive behavior and rare distant metastasis. Complete surgical excision is the preferred treatment for SCCs, yet its feasibility is often constrained by tumor invasiveness and anatomical limitations. Electrochemotherapy (ECT) has emerged as a promising alternative, utilizing electroporation to enhance intracellular drug uptake while minimizing systemic toxicity. Bleomycin and cisplatin have been successfully used in avian intralesional chemotherapy, offering a potentially safer and effective treatment approach. ECT has demonstrated efficacy in various exotic species, yet its application in raptors remains largely unexplored. This case report describes the use of electrochemotherapy with bleomycin in a peregrine falcon diagnosed with SCC, contributing to the growing body of evidence supporting its clinical utility in avian oncology.