Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Vulvar squamous cell carcinoma (VSCC) is subdivided into TP53-mutant (TP53) and HPV-associated (HPV). In recent years, a third group unrelated to TP53 mutation or HPV-association (TP53/HPV) has emerged. However, its prognosis is unclear.
Objective: The aim of this study was to define the prognosis of TP53/HPVVSCC through a systematic review and meta-analysis.
Methods: Electronic databases were searched from their inception to February 2025 for studies comparing the prognosis of TP53/HPV VSCC to that of TP53 and HPV VSCC. Pooled hazard ratios (HR) for recurrence-free survival (RFS) and disease-specific survival (DSS) were calculated, with a significant p-value<0.05.
Results: Six studies were included in the systematic review, while 5 studies with 1355 VSCCs (755 TP53, 302 HPV, 298 TP53/HPV) were included in the meta-analysis. TP53/HPV VSCC showed significantly better PFS (HR = 0.714; p = 0.022) and DSS (HR = 0.633; p = 0.037) than TP53 VSCC and significantly worse PFS (HR = 2.555; p = 0.001) and DSS (HR = 1.973; p = 0.024) than HPV VSCC.
Conclusions: TP53/HPV VSCCs constitute a group at intermediate risk, with a prognosis significantly better than TP53 VSCC and significantly worse than HPV VSCC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ygyno.2025.08.028 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prognosis of HPV-independent, p53-wild-type vulvar squamous cell carcinoma: A systematic review and meta-analysis.
Gynecol Oncol
September 2025
Pathology Unit, Department of Oncology, ASST Sette Laghi, Varese, Italy; Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy. Electronic address:
Background: Vulvar squamous cell carcinoma (VSCC) is subdivided into TP53-mutant (TP53) and HPV-associated (HPV). In recent years, a third group unrelated to TP53 mutation or HPV-association (TP53/HPV) has emerged. However, its prognosis is unclear.
View Article and Find Full Text PDFSquamous Cell Carcinoma of the Vulva in Geriatric With Clinical Features of Papillomatous Plaque Resembling Anogenital Warts Caused by Human Papillomavirus Types 6 and 11.
Case Rep Dermatol Med
August 2025
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.
Squamous cell carcinoma (SCC) of the vulva is caused by disturbances in the proliferation and differentiation of the squamous epithelium, which can be associated with human papillomavirus (HPV) infection. Vulvar SCC is usually caused by high-risk HPV types, although there are some cases that are caused by low-risk HPV types. The clinical manifestations of vulvar SCC vary, one of which can resemble anogenital warts.
View Article and Find Full Text PDFAssessment of Nectin4-expression in vulvar squamous cell carcinomas (VSCC): correlation with HPV-associated and HPV-independent molecular subtypes.
Hum Pathol
September 2025
Division of Gynecologic, Breast and Perinatal Pathology, Institute of Pathology, University Hospital Leipzig, Germany.
Background: The development of antibody-drug conjugates (ADC) for cancer treatment has achieved promising results in different solid tumors and targets. Enfortumab-Vedotin (EV), a humanised anti-Nectin4-IgG1 monoclonal antibody linked to the microtubule-disrupting agent monomethyl auristatin E (MMAE), is an FDA-approved Nectin4-directed ADC for the treatment of locally advanced or metastatic pre-treated urothelial cancer. Targeted therapy with EV requires the expression of Nectin4 within the tumor cells.
View Article and Find Full Text PDFThe Peritoneal Neovagina After Robotic-Assisted Peritoneal Flap Gender-Affirming Vaginoplasty: A Morphologic and Histologic Investigation of the Neovaginal Lining.
Urology
September 2025
Oregon Health & Science University, Division of Plastic & Reconstructive Surgery, Portland, OR, USA; Oregon Health & Science University, Department of Urology, Portland, OR, USA. Electronic address:
Objectives: To assess histologic changes in the peritoneal neovagina following RPGAV to better guide shared decision-making regarding vaginoplasty techniques. Robotic-Assisted Peritoneal Flap Gender-Affirming Vaginoplasty (RPGAV) uses pedicled flaps of pelvic peritoneum to form the proximal neovagina. Early reports of peritoneal vaginoplasty suggested potential for "self-lubrication"; however, long-term maintenance of fluid production remains uncertain.
View Article and Find Full Text PDFManagement of aberrant crossing of superficial external pudendal artery during robotic video-endoscopic inguinofemoral lymphadenectomy: a video case study.
J Robot Surg
September 2025
Panbirmingham Gynaecological Cancer Centre, Midland Metropolitan University Hospital, Grove Lane, Smethwick, Birmingham, B66 2QT, UK.
Inguinofemoral lymphadenectomy remains a critical component of staging and treatment for vulvar and penile squamous cell carcinoma. Traditionally performed via an open approach, this procedure is associated with significant morbidity, including lymphocyst formation, chronic lymphedema, and delayed recovery. A minimally invasive alternative, via laparoscopic or robotic platforms, is gaining traction as it is associated with a lower risk of surgical morbidity.
View Article and Find Full Text PDF