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http://dx.doi.org/10.1016/j.tmaid.2025.102854 | DOI Listing |
Cell Rep
September 2025
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Pôle de Recherches Sino-Français en Science du Vivant et Gé
RNA helicase DDX3X is generally implicated in inflammasome activation and anti-viral responses. We characterize the common features of scattered DDX3X mutations in lymphoid cancers using molecular dynamics simulation and crystallization, thereby demonstrating their crucial role in Epstein-Barr virus (EBV) lytic gene-driven oncogenic processes. The DDX3X mutation is significantly related to impaired stimulator of interferon genes (STING)/ interferon regulatory factor 7 (IRF-7)/interferon (IFN)-α/β-mediated innate immunity, overexpression of EBV lytic gene BNLF2b, and increased formation of R-loops.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Department of Planned Immunization, Chaoyang District Centre for Disease Control and Prevention, Beijing, China.
Mumps is a vaccine-preventable disease. Following Beijing's implementation of a three-dose MMR vaccination strategy, incidence rates declined significantly. However, the current 21-d quarantine period lacks evidence-based support, resulting in low compliance and conflicts between healthcare providers and patients.
View Article and Find Full Text PDFWater Res
August 2025
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an, 710069, China; The Collaboration Unit for State Key Laboratory of Infectious Disease Prevention and Control, Jiangxi Provincial Health Commission Key Laborat
Human parainfluenza virus (HPIV) and human rhinovirus (HRV) significantly contribute to acute respiratory tract infections (ARIs), especially in children. Wastewater surveillance (WWS) is a valuable tool for monitoring these viruses, but limited understanding of their fecal shedding patterns restricts the broader application of WWS. This study aimed to investigate fecal shedding dynamics of HPIV and HRV for developing a mass-balance model to predict infection prevalence, and conduct wastewater sequencing to explore genetic diversity.
View Article and Find Full Text PDFEmerg Microbes Infect
September 2025
State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Prevention & Control for African Swine Fever and Other Major Pig Diseases, Ministry of Agriculture and Rural Affairs, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
African swine fever virus (ASFV) causes a lethal hemorrhagic disease in domestic pigs and represents a major threat to the global swine industry. Until now, no effective commercial vaccines or antiviral drugs are available for ASF control. In this study, we constructed a recombinant E120R gene-deleted virus, ASFV-ΔE120R, based on the highly virulent genotype II strain SY18, to investigate the biological role of the E120R gene.
View Article and Find Full Text PDFMol Ther Methods Clin Dev
September 2025
Division of Medicinal Safety Science, National Institute of Health Sciences, Kanagawa 210-9501, Japan.
Assessment of the biodistribution and shedding is required for the development of viral vector-based vaccines. Vector copy number is commonly quantified using digital PCR (dPCR) or quantitative PCR (qPCR). However, the regulatory guidelines for bioanalytical PCR assays have not been released at present.
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