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http://dx.doi.org/10.1002/cac2.70026 | DOI Listing |
Adv Sci (Weinh)
September 2025
Department of Physics, State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Science (Ministry of Education), Fudan University, 2005 Songhu Road, Yangpu District, Shanghai, 200433, China.
Emerging evidence indicates that liquid-liquid phase separation of α-synuclein occurs during the nucleation step of its aggregation, a pivotal step in the onset of Parkinson's disease. Elucidating the molecular determinants governing this process is essential for understanding the pathological mechanisms of diseases and developing therapeutic strategies that target early-stage aggregation. While previous studies have identified residues critical for α-synuclein amyloid formation, the key residues and molecular drivers of its phase separation remain largely unexplored.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong518055, China.
The rapid development of liquid exfoliation technology has boosted fundamental research and applications of ultrathin two-dimensional (2D) materials. However, the small-sized exfoliated 2D materials with a high specific surface area may exhibit poor chemical stability. Understanding the stability of 2D crystals will be significant for their preservation and service and for the development of new stable phases via the spontaneous transition from unstable structures.
View Article and Find Full Text PDFDalton Trans
September 2025
Departamento de Fisica Aplicada-ICMUV, MALTA Consolider Team, Universitat de Valencia, Av. Dr. Moliner 50, 46100 Burjassot (Valencia), Spain.
The impact of external pressure on the characteristics of SrTeO has been thoroughly examined using density-functional theory calculations up to 100 GPa. It has been predicted that SrTeO undergoes three phase transitions in the pressure range covered by this study. A first transition occurs at 2.
View Article and Find Full Text PDFDiabetes Obes Metab
September 2025
Eli Lilly and Company, Indianapolis, Indiana, USA.
Aims: To determine whether adults with type 2 diabetes (T2D) treated with retatrutide report greater changes in self-reported appetite, dietary restraint, and disinhibition compared to placebo or dulaglutide and to examine associations with weight change.
Materials And Methods: These pre-specified exploratory analyses examined changes from baseline in Appetite Visual Analogue Scale (VAS) and Eating Inventory (EI) scores after 24 and 36 weeks of once-weekly treatment with placebo, dulaglutide 1.5 mg, or retatrutide 0.
Physiol Plant
September 2025
Agriculture and Agri-Food Canada, Saskatoon Research and Development Centre, Saskatoon, Saskatchewan, Canada.
Dormancy release and germination of the seed are two separate, but continuous phases controlled by both external (e.g., light and temperature) and internal (e.
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