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This article examines instructions on the handling of medicines produced by a Finnish hospital pharmacy from the perspectives of two reader concepts: the model reader and the reader-in-the-text. The former comprises virtually all the medical professionals working in diverse wards, and two group interviews with hospital pharmacists are used to explore how instruction writers orientate to this versatile readership and construct model readers. The concept of "reader-in-the-text" is then used to examine 22 instruction texts from the perspective of textual interaction. The analysis reveals that the writers construct an "official" model reader, who is anyone working in healthcare, but also that more informal, profession-specific model readers are introduced. The official model reader is reflected in the text documents as a collection of impersonal features and term explanations. What is required from the reader-in-the-text to navigate the instructions successfully is background knowledge of the organizational division of labor.
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http://dx.doi.org/10.3138/cam-2025-0203 | DOI Listing |
World J Urol
September 2025
Division of Urology, University of Montreal Hospital Centre, Montreal, QC, Canada.
Purpose: To report the level of knowledge, impressions, and satisfaction of Urology readers, authors, and editorial boards regarding Open Access (OA) publishing in the field of Urology and to determine their satisfaction with the current OA models.
Methods: We developed an online, five-section cross-sectional survey including 23 questions. To recruit participants, we used mixed methods to obtain responses based on a simple random sampling and convenience sampling.
Magn Reson Med
September 2025
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Purpose: Gadoxetic acid-enhanced hepatobiliary phase T-weighted (Tw) MRI is effective for the detection of focal liver lesions but lacks sufficient T contrast to distinguish benign from malignant lesions. Although the addition of T, diffusion, and dynamic contrast-enhanced Tw imaging improves lesion characterization, these methods often do not provide adequate spatial resolution to identify subcentimeter lesions. This work proposes a high-resolution, volumetric, free-breathing liver MRI method that produces colocalized fat-suppressed, variable Tw images from a single acquisition, thereby improving both lesion detection and characterization.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520.
A frequent goal of phage biology is to quantify how well a phage kills a population of host bacteria. Unfortunately, traditional methods to quantify phage success can be time-consuming, limiting the throughput of experiments. Here, we use theory to show how the effects of phages on their hosts can be quantified using bacterial population dynamics measured in a high-throughput microplate reader (automated spectrophotometer).
View Article and Find Full Text PDFRSC Med Chem
September 2025
NodThera Ltd. Suite 8, The Mansion, Chesterford Research Park, Little Chesterford, Saffron Walden Essex CB10 1XL UK
Inhibition of the NLRP3 inflammasome has emerged as a high potential treatment paradigm for the treatment of neuroinflammation, with demonstrated anti-neuroinflammatory effects in Parkinson's disease patients and a strong rationale in Alzheimer's disease and amyotrophic lateral sclerosis. To facilitate further progress in this field, brain penetrant NLRP3 inflammasome inhibitors as leads and tool compounds are required. We discovered a small molecule NLRP3 inflammasome inhibitor, NT-0527 (11), and extensively profiled this to reveal a highly potent, selective and brain penetrant compound.
View Article and Find Full Text PDFProg Nucl Magn Reson Spectrosc
September 2025
Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic. Electronic address:
In-cell NMR spectroscopy has recently emerged as a unique source of atomically resolved information on the structure, dynamics, and interactions of nucleic acids (NAs) within the intracellular space of living cells. Its recent applications have helped reveal fundamental differences in the behaviour of NAs in cells compared to the in vitro conditions commonly used for their study, as well as in physiologically distinct cellular states. This review covers the fundamental principles and practical aspects of acquiring in-cell NMR data in currently established eukaryotic cellular models, Xenopus laevis oocytes, and human cells.
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