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Background: Lipid Accumulation Product (LAP) is a biomarker associated with excessive lipid accumulation and various metabolic diseases. Despite the well-established link between oral and systemic health, the association between LAP and oral health remains largely unexplored.
Methods: Data from 7,124 participants aged over 18 years from the National Health and Nutrition Examination Survey (NHANES) between 2009 and 2014 were analyzed. Multivariate logistic regression models were applied to evaluate the independent association between LAP and self-reported oral health outcomes, adjusting for potential confounders.
Results: There was a significant correlation between increasing LAP levels and deteriorating oral health status (β = 0.26, 95% CI: 0.20 to 0.32, P < 0.0001). Subgroup analyses revealed that the negative correlation between LAP and self-reported oral health outcomes was more pronounced in younger individuals and those with higher education levels. A non-linear relationship was identified, with oral health deteriorating significantly as LAP increased up to a threshold of 83, after which the relationship became non-significant.
Conclusions: This study demonstrates a robust association between LAP and self-reported oral health outcomes, suggesting that LAP could be a reliable indicator for assessing oral health status. The findings highlight the importance of targeted health interventions for populations with higher LAP indices to prevent oral health deterioration and potential systemic health issues.
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http://dx.doi.org/10.1186/s12944-025-02543-4 | DOI Listing |
Adv Sci (Weinh)
September 2025
Department of Orthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key
Clear aligners offer aesthetic and comfort advantages in orthodontics, yet their ability to deliver effective forces relies heavily on empirical judgment or large-scale optical scanning, lacking real-time quantitative evaluation. Integrating pressure sensors into aligners is a promising solution, but challenges in miniaturization, multi-dimensional sensing, measurement accuracy, and biocompatibility hinder clinical application. Here, an all-in-one Orthodontic Force Acquisition System (OFAS) is presented that enables real-time, 3D force monitoring using a cross-shaped iontronic sensing array and an origami-inspired, wireless battery-free readout circuit miniaturized for single-tooth placement.
View Article and Find Full Text PDFFoot Ankle Int
September 2025
Department of Orthopaedic Surgery, St. Luke's University Health Network, Bethlehem, PA, USA.
Background: In response to the opioid epidemic, many surgical specialties have adopted nonopioid pain management strategies. Ultrasound (US)-guided peripheral nerve blocks (PNBs) are effective in reducing pain and opioid consumption postsurgery. Liposomal bupivacaine (LB), shown effective in shoulder surgery, was approved in November 2023 for use in US-guided lower extremity blocks.
View Article and Find Full Text PDFAllergy
September 2025
Department of Paediatrics, Division of Pneumology, Allergology, Infectious Diseases and Gastroenterology, Goethe University Frankfurt, Frankfurt am Main, Germany.
Premastication, or pre-chewing, of food as a feeding practice for infants has been practiced across cultures as an ancient evolutionary method. Whilst literature on the topic remains slim, the majority of existing research has highlighted the potential risks, such as transmission of infections. Although the concerns are valid, potential beneficial aspects have, until now, received less attention.
View Article and Find Full Text PDFJ Palliat Med
September 2025
Middle East Cancer Consortium, Haifa, Israel.
Despite a plethora of evidence available on the benefits of palliative care (PC), it is estimated that only about 14% of those living in low- to middle-income countries (LMIC) or developing countries have access to PC. To globally examine PC expert perspectives regarding PC infrastructure and resources within each country, drug and opioid availability to provide PC, and workforce and educational issues. Descriptive, open-ended survey seeking first-hand qualitative perspectives.
View Article and Find Full Text PDFAust Endod J
September 2025
Department of Forensic Dentistry and Public Health, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
This systematic review examined the relationship between sickle cell disease (SCD), an inherited genetic hemoglobinopathy, and avascular pulp necrosis (APN) in intact teeth. A comprehensive search of eight electronic databases was performed up to December 2024. Eligible studies included observational or interventional designs reporting APN in intact teeth of individuals with SCD.
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