Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Type 2 diabetes mellitus (T2DM) is a major driver of coronary atherosclerosis progression, yet its impact is highly heterogeneous. Insulin resistance contributes to a complex interplay of metabolic disturbances that accelerate atherogenesis to varying degrees. Identifying biomarkers that refine cardiovascular risk prediction in this population remains a clinical priority.
Objective: To evaluate the association between small HDL particle concentration and the incidence/progression of coronary artery calcium (CAC) in individuals with T2DM.
Methods: We analyzed 4,331 participants from the ELSA-Brasil cohort. CAC incidence/progression was compared between individuals with and without T2DM. A subgroup of 461 non-statin users with T2DM and no baseline atherosclerotic cardiovascular disease (ASCVD) was further assessed for associations between small HDL particles (<8nm, HDLp1) and CAC outcomes.
Results: Individuals with T2DM showed increased CAC incidence/progression rates compared to non-diabetic participants. Among 461 non-statin users with T2DM, 143 (31.0%) experienced CAC incidence/progression. Higher plasma concentrations of HDLp1 (3rd tertile) were associated with a 140% (95%CI 32-341%, p<0.001) greater likelihood of CAC incidence/progression compared to the 1st tertile. The inclusion of HDLp1 significantly improved CAC risk classification, with a net reclassification improvement (NRI) of 13.6% (95%CI 2.8-18.8%, p=0.004).
Conclusion: HDLp1 concentration is significantly associated with CAC incidence/progression in individuals with T2DM and may improve risk discrimination for coronary atherosclerosis progression in this population.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1210/clinem/dgaf215 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unfluctuating diastolic pressure, stiff arteries - the unseen culprits behind the curtain of cognitive decline: An observational study.
Medicine (Baltimore)
September 2025
Department of Geriatrics, Lianyungang Hospital Affiliated to Jiangsu University, Lianyungang, China.
Cerebral small-vessel disease (CSVD) is an important risk factor for cognitive impairment, which is a pressing health issue for the aging population worldwide. The complex relationship between vascular factors, such as blood pressure variability (BPV) and arteriosclerosis index (AI), and cognitive dysfunction in patients with CSVD is a hot research topic, and research in this area will help prevent and treat cognitive dysfunction in CSVD. This study aims to investigate the effects of diastolic BPV (DBPV) and AI on cognitive function in patients with CSVD.
View Article and Find Full Text PDFSerum Lipid Profiles as Predictors of Hemorrhagic Transformation After Thrombolysis in Acute Cerebral Infarction: A Prospective Study.
Curr Neurovasc Res
August 2025
The Second Affiliated Hospital of Chongqing Medical University, China, No. 76, Linjiang Road, Yuzhong District, Chongqing, China.
Introduction: This study aims to investigate the effect of the serum Total Cholesterol (TC) to High-Density Lipoprotein cholesterol (HDL) ratio (T/H ratio) on Hemorrhagic Transformation (HT) after Intravenous Thrombolysis (IVT) in patients with Acute Cerebral Infarction (ACI).
Methods: Patients with ACI who received alteplase were enrolled. Subgroups were classified based on the occurrence of hemorrhagic transformation (HT) after intravenous thrombolysis (IVT), whether tirofiban was coadministered, and their 90-day prognosis.
HDL remodeling and enrichment with apoCIII and apoE in Indigenous Australians.
J Clin Lipidol
August 2025
ANZAC Research institute, Concord Repatriation General Hospital and University of Sydney, Sydney, NSW, Australia (Drs Kockx, Wang, and Kritharides); Department of Cardiology, Concord Repatriation General Hospital, Sydney Local Health District and University of Sydney, Sydney, NSW, Australia (Dr Krit
Background: Indigenous Australians have an increased risk of type 2 diabetes mellitus (T2DM) and premature cardiovascular disease. Subpopulations of high-density lipoprotein (HDL) have been associated with increased cardiovascular risk, but HDL composition, size, or function have not been studied in Indigenous Australians.
Methods: The study consisted of 86 non-Indigenous participants, 43 of whom had T2DM, and 75 Indigenous participants, 36 of whom had T2DM.
Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study.
Lancet Reg Health Eur
September 2025
Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, Munich, Germany.
Background: Stroke survivors frequently experience subsequent cognitive impairment or dementia. We aimed to identify risk factors for post-stroke dementia (PSD) and cognitive impairment (PSCI) within 5 years after stroke.
Methods: The DEMDAS (German Center for Neurological Diseases (DZNE) mechanisms of dementia after stroke) study is a prospective cohort of stroke patients admitted to six German tertiary stroke centres between May 1, 2011 and January 31, 2019.
Mediterranean diet and associated metabolite signatures in relation to MASLD progression: A prospective cohort study.
Hepatol Commun
September 2025
Department of Epidemiology and Biostatistics, Clinical Big Data Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Background: Mediterranean diet (MED) is recommended for managing metabolic dysfunction-associated steatotic liver disease (MASLD). However, associations between MED adherence, related metabolite signatures, and risks of liver-related events (LRE) and mortality in MASLD patients remain unclear.
Methods: We performed a prospective analysis using UK Biobank data, including 47,429 MASLD participants free of LRE at baseline.