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Minor neurocognitive disorders (NCDs) represent a transitional phase between normal cognitive aging and dementia, highlighting the importance of early interventions. This study assessed the efficacy of a structured 6-month computerized cognitive training (CCT) program in stabilizing cognitive decline among older adults with minor NCDs. One hundred participants were randomly assigned to an intervention group or a non-intervention group. The intervention group underwent weekly, personalized CCT sessions using the MeMo program, which targeted memory, attention, and adaptability. Cognitive performance was measured at baseline and after six months using the Cambridge Cognitive Examination (CAMCOG). Statistical analysis showed significant cognitive decline in the non-intervention group in orientation ( = 0.032), language expression ( = 0.008), praxis ( = 0.008), and memory ( = 0.01). In contrast, the intervention group showed no significant changes, except for a minor decline in perception ( = 0.003). These results suggest that CCT may help delay cognitive deterioration in minor NCDs. However, while cognitive decline was stabilized, no significant improvement was observed. Further research is recommended to investigate the long-term benefits and the transferability of cognitive gains. The findings support the use of CCT as a non-pharmacological health promotion strategy for enhancing cognitive resilience in aging populations. The novelty of this research lies in its focus on adaptive CCT as a non-pharmacological intervention, highlighting the potential role of neuroplasticity in delaying cognitive decline and offering new insights into personalized cognitive health strategies for aging populations.
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http://dx.doi.org/10.3390/ejihpe15030034 | DOI Listing |
J Neuropsychiatry Clin Neurosci
September 2025
Departments of Psychiatry and Neurology, Center for Brain/Mind Medicine, and Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston.
Brain Behav
September 2025
Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Background And Purpose: White matter hyperintensity (WMH) impairs cognitive function but is not evident in the early stage, raising the need to explore the underlying mechanism. We aimed to investigate the potential role of network structure-function coupling (SC-FC coupling) in cognitive performance of WMH patients.
Methods: A total of 617 participants with WMH (mean age = 61 [SD = 8]; 287 females [46.
Schizophr Bull
September 2025
Department of Psychiatry, Central Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Background And Hypothesis: Schizophrenia is linked to hippocampal dysfunction and microglial inflammatory activation. Our prior clinical findings revealed significantly reduced transient receptor potential vanilloid 1 (TRPV1) expression in both first-episode and recurrent schizophrenia patients, with levels inversely correlating with symptom severity, implicating TRPV1 dysfunction in disease progression. Preclinical maternal separation (MS) models recapitulate schizophrenia-like behavioral and synaptic deficits, paralleled by hippocampal microglial TRPV1 downregulation.
View Article and Find Full Text PDFJ Am Acad Audiol
September 2025
Given the evidence of cognitive deficits in individuals with vestibular dysfunction, reduced cognitive resources may impact the effort required to process auditory information, particularly in adverse listening conditions. Although existing literature suggests impaired performance on cognitive tasks in vestibular disorders in general, research in this area specific to patients with vestibular migraine is limited. This article aims to investigate working memory, auditory attention, and listening effort among individuals with vestibular migraine.
View Article and Find Full Text PDFBrain Behav
September 2025
Department of Neurology, NHO Nishiniigata Chuo Hospital, Niigata, Japan.
Background: Y69H (p.Y89H) variant hereditary transthyretin (ATTRv) amyloidosis causes meningeal amyloidosis, with mutant TTR deposits localized to the leptomeninges and vitreous body.
Methods: The effect of tafamidis meglumine on neurological disorders, such as the frequency of transient focal neurological episodes (TFNEs), magnetic resonance imaging (MRI) findings, and TTR levels in cerebrospinal fluid, was investigated in two patients diagnosed with Y69H ATTRv mutation.