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http://dx.doi.org/10.1093/eurjpc/zwaf171 | DOI Listing |
EMBO Rep
September 2025
Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK post, Bellary Road, Bangalore, Karnataka, 560065, India.
Immune cells are increasingly recognized as nutrient sensors; however, their developmental role in regulating growth under homeostasis or dietary stress remains elusive. Here, we show that Drosophila larval macrophages, in response to excessive dietary sugar (HSD), reprogram their metabolic state by activating glycolysis, thereby enhancing TCA-cycle flux, and increasing lipogenesis-while concurrently maintaining a lipolytic state. Although this immune-metabolic configuration correlates with growth retardation under HSD, our genetic analyses reveal that enhanced lipogenesis supports growth, whereas glycolysis and lipolysis are growth-inhibitory.
View Article and Find Full Text PDFFish Shellfish Immunol
September 2025
State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, State Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture and Rural Affairs, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; College of Advanced Agricultural Sciences, Universi
Metaflammation, a chronic immune response triggered by metabolic dysregulation, poses significant threats to gut-liver homeostasis in aquaculture species. To understand the progression of metaflammation, it is crucial to examine the role of SOCS8 deficiency in socs8 zebrafish, as this species may serve as a disease model for metabolic disorders due to the gradual dysregulation of immunity, metabolism, and the gut microbiota observed in them. This study examines the immune-metabolic crosstalk in grass carp, subjected to soybean meal-induced enteritis, and in socs8 zebrafish under genetic and dietary stress.
View Article and Find Full Text PDFPhysiol Genomics
September 2025
Department of Bioinformatics, University of Würzburg, Am Hubland, 97074 Würzburg , Germany.
The human microbiome is emerging as a key regulator of cancer biology, modulating tumor development, immune dynamics, and therapeutic responses across diverse malignancies. In this review, recent insights are synthesized regarding how microbial communities (bacterial, fungal, and viral) shape oncogenic signaling, immune checkpoint blockade (ICB) efficacy, and metabolic reprogramming in lung, pancreatic, colorectal, breast, cervical, melanoma, and gastric cancers. Mechanistic links between microbial metabolites, intratumoral colonization, and host immune phenotypes are highlighted proposing that the microbiome constitutes a programmable axis within the tumor immune-metabolic ecosystem.
View Article and Find Full Text PDFStem Cell Res Ther
August 2025
Department of Stomatology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China.
Periodontitis is a chronic inflammatory disease that damages periodontal tissues and is mainly caused by immune dysfunction. Current treatments, such as mechanical debridement and adjunctive antimicrobial, work poorly; periodontal surgery brings pain and complications.Mesenchymal stem cells (MSCs) have a powerful ability to regulate immune responses and great potential for tissue regeneration, thus attracting extensive attention in the field of periodontal treatment.
View Article and Find Full Text PDFFish Physiol Biochem
August 2025
The New Zealand Institute for Plant and Food Research Limited, Nelson, 7043, New Zealand.
Promoting swimming in aquaculture has been proposed to enhance fish welfare. This study investigated the effects of 6 h of swimming on stress, immune, metabolic, and antioxidant status of juvenile rainbow trout (Oncorhynchus mykiss). Fish (n = 8) were individually subjected to one of four experimental conditions: minimal water flow (control, < 0.
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