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Article Abstract
Chemical investigation of the mangrove-derived fungus sp. DHS-11 led to the isolation of three new pyrone derivatives (-), and a new natural product (). Their structures were identified by NMR spectroscopy and mass spectrometry. The configurations for the new pyrone derivatives were tentatively solved by comparison of C NMR data and analysis of the coupling constants and NOESY correlations. Compounds and exhibited significant cytotoxicity against HepG2 with IC values of 4.66 ± 0.35 µM and 6.07 ± 0.48 µM, respectively. Compound showed moderate cytotoxicity against Hela cells with IC value of 20.2 ± 4.93 µM.
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New polyketides from the mangrove-associated endophytic fungus sp. DHS-11.
J Asian Nat Prod Res
March 2025
School of Chemistry and Chemical Engineering, Hainan University, Haikou 570208, China.
Chemical investigation of the mangrove-derived fungus sp. DHS-11 led to the isolation of three new pyrone derivatives (-), and a new natural product (). Their structures were identified by NMR spectroscopy and mass spectrometry.
View Article and Find Full Text PDFInduction of Three New Secondary Metabolites by the Co-Culture of Endophytic Fungi DHS-48 and sp. DHS-11 Isolated from the Chinese Mangrove Plant .
Mar Drugs
July 2024
Collaborative Innovation Center of Ecological Civilization, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China.
Co-cultivation is a powerful emerging tool for awakening biosynthetic gene clusters (BGCs) that remain transcriptionally silent under artificial culture conditions. It has recently been used increasingly extensively to study natural interactions and discover new bioactive metabolites. As a part of our project aiming at the discovery of structurally novel and biologically active natural products from mangrove endophytic fungi, an established co-culture of a strain of DHS-48 with another genus fungus DHS-11, both endophytes in mangrove , proved to be very efficient to induce the production of new metabolites as well as to increase the yields of respective target metabolites.
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Collaborative Innovation Center of Ecological Civilization, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China.
The co-culture strategy, which mimics natural ecology by constructing an artificial microbial community, is a useful tool for the activation of biosynthetic gene clusters (BGCs) to generate new metabolites, as well as to increase the yield of respective target metabolites. As part of our project aiming at the discovery of structurally novel and biologically active natural products from mangrove endophytic fungi, we selected the co-culture of a strain of DHS-48 with another genus fungus DHS-11, both endophyted in mangrove considering the impart of the taxonomic criteria and ecological data. The competition interaction of the two strains was investigated through morphology observation and scanning electron microscopy (SEM), and it was found that the mycelia of the DHS-48 and DHS-11 compacted and tangled with each other with an interwoven pattern in the co-culture system.
View Article and Find Full Text PDFNew Isocoumarin and Pyrone Derivatives from the Chinese Mangrove Plant -Associated Fungus sp. DHS-11.
Molecules
April 2023
School of Chemical Engineering and Technology, Hainan University, Haikou 570208, China.
Mangrove-associated fungi are important sources for the discovery of new bioactive natural products. Three new isocoumarins (-) and one new pyrone derivative () were isolated from the ethyl acetate extract of the fermentation broth of the mangrove endophytic fungus sp. DHS-11.
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