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Background: Myocardial bridge contributes to chest pain, often accompanied by non-specific complaints.
Aims: Our study aims to determine somatic symptom disorder (SSD) prevalence in patients with myocardial bridge, investigating associated clinical and psychological features.
Method: In this prospective cross-sectional study, we enrolled 1357 participants (337 with and 1020 without myocardial bridge) from Shanghai Renji Hospital. The Somatic Symptom Scale-China questionnaire was used to assess SSD. Depressive and anxiety disorders were assessed by the Patient Health Questionnaire-9 (PHQ-9) and Generalised Anxiety Disorder-7 (GAD-7).
Results: The prevalence of SSD in the myocardial bridge group was 63.2%, higher than the group without myocardial bridge (53.8%). Patients with myocardial bridge were at an increased risk of SSD (odds ratio 1.362, 95% CI 1.026-1.809; = 0.033). There were no differences in the mean PHQ-9 scores (3.2 ± 3.4 . 3.2 ± 4.1; = 0.751) or GAD-7 scores (2.5 ± 3.0 . 2.3 ± 3.7; = 0.143) between the two groups. Among patients with myocardial bridge, gender was the only independent risk factor for SSD. Women were 3.119 times more likely to experience SSD compared with men (95% CI 1.537-6.329; = 0.002).
Conclusions: Our findings emphasise the high prevalence and severity of SSD among patients with myocardial bridge. The screening for SSD should be of particular concern, especially among female patients.
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http://dx.doi.org/10.1192/bjo.2024.851 | DOI Listing |
Front Biosci (Landmark Ed)
August 2025
Institute of Biomedical Sciences, Faculty of Medicine, 8380000 Santiago, Chile.
Acute myocardial infarction (AMI) is one of the main causes of mortality worldwide. Currently, the most effective treatment is percutaneous coronary angioplasty (PCA). However, paradoxically, the restoration of blood flow induces myocardial reperfusion injury (MRI), contributing up to 50% of the final infarct size.
View Article and Find Full Text PDFAm J Cardiol
September 2025
Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua, Italy. Electronic address:
Introduction: A myocardial bridge (MB) is a condition where a segment of an epicardial coronary artery passes through the myocardial muscle. While traditionally regarded as benign, MBs have been associated with various cardiovascular conditions. Therefore, assessing their hemodynamic impact is crucial for informed treatment decisions.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, P. R. China.
Mitigating myocardial ischemia-reperfusion (IR) injury is essential for enhancing the success of heart transplantation (HT) and improving patient outcomes. During HT, infiltrating neutrophils are influenced and regulated by various other cell types, contributing to myocardial IR injury through the excessive release of neutrophil extracellular traps (NETs). Nonetheless, the precise mechanisms underlying the interactions between neutrophils and other non-cardiomyocytes remain largely unexplored.
View Article and Find Full Text PDFActa Pharm Sin B
August 2025
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
Mitochondrial DNA (mtDNA) acts as a damage-associated molecular pattern to activate the stimulator of interferon genes (STING) signaling in macrophages, promoting tissue inflammation. However, its role in acute myocardial infarction (AMI) remains unclear. Macrophage-specific knockout mice were used to validate STING's pathological role in AMI.
View Article and Find Full Text PDFAm J Med
September 2025
British Medical Association, BMA House, London, UK. Electronic address: