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The spin Hall effect of light (SHEL), the transverse splitting of light into two circularly polarized components via refraction or reflection, offers high-precision, nondestructive inspection of unknown interfaces when combined with a signal amplification technique called weak measurement. However, its application in detecting dynamics is limited due to its multistep process. Here, we condense the procedure into a single step, enabling calibration-free, single-shot measurement of the SHEL by replacing one component of the conventional setup with a polarization beamsplitting metasurface. Our approach allows for instantaneous evaluation of the SHEL, even with fluctuations in the original beam position. As proof of concept, we apply metasurface-assisted weak measurements to both static and dynamic scenarios, where the experimental results obtained from a single captured image demonstrate nice agreement with theory. This real-time observation of the SHEL highlights its potential for high-precision monitoring of dynamic processes such as biomedical sensing and chemical analysis.
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http://dx.doi.org/10.1038/s41467-025-56728-7 | DOI Listing |
Biomol Biomed
September 2025
Clinical Research Directorate, Ignacio Chávez National Institute of Cardiology, Mexico City, Mexico.
Rheumatoid arthritis (RA) is a chronic autoimmune disease in which dysregulated interferon regulatory factor 5 (IRF5) may amplify pro-inflammatory pathways; prior genetic studies of IRF5 single-nucleotide variants (SNVs) in RA are inconsistent across populations and have not included mestizo Mexicans or evaluated rs59110799 in RA. We aimed to test whether four IRF5 SNVs (rs2004640G/T, rs2070197T/C, rs10954213G/A, rs59110799G/T) confer susceptibility to RA in women from Central Mexico. In a case-control study of 239 women with RA and 231 female controls (all self-identified Mexican-Mestizos, ≥3 generations), genotyping was performed by real-time PCR with TaqMan® probes; 80% of samples were duplicated (100% concordance) and control genotypes conformed to Hardy-Weinberg equilibrium.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
September 2025
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Despite significant advancements in the treatment of non-small cell lung cancer (NSCLC) using conventional therapeutic methods, drug resistance remains a major factor contributing to disease recurrence. In this study, we aimed to explore the potential benefits of combining PI3K inhibition with Cisplatin in the context of NSCLC-derived A549 cells. Human non-small cell lung cancer A549 cells were cultured and treated with BKM120, cisplatin, or their combination.
View Article and Find Full Text PDFTransl Neurosci
January 2025
Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, P.R. China.
Objectives: Excessive neuroinflammatory responses represent a key pathological mechanism in cerebral small vessel disease (CSVD). Dl-3--butylphthalide (NBP), a compound previously demonstrated to possess anti-inflammatory properties in ischemic stroke, was investigated for its potential therapeutic effects in a rodent model of CSVD. This study aimed to elucidate the neuroprotective mechanisms of NBP in CSVD pathogenesis.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Gastroenterology, Shaanxi Provincial People's Hospital, Xi'an, China.
Background: Azygos vein aneurysm (AVA) is a rare thoracic pathology that is frequently misdiagnosed. While contrast-enhanced chest computed tomography (CT) or magnetic resonance imaging (MRI) can delineate AVA location and size, these techniques lack the capability for dynamic real-time assessment of internal architecture.
Case Presentation: We present a highly unusual case of a 67-year-old woman who had an isolated azygos vein aneurysm presenting with dysphagia.
Front Oncol
August 2025
Department of Infectious Biology, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, India.
Introduction: Ovarian cancer has a high mortality rate due to late diagnosis, relapse and chemoresistance. miRNAs play a major role in tumorigenesis as well as chemoresistance. Hence, we undertook a study, to evaluate the differential expression of miRNAs in clinical specimens of ovarian cancer patients that may highlight the effect of chemotherapy and their role in predicting survival outcomes.
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