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http://dx.doi.org/10.1007/s00216-025-05774-7 | DOI Listing |
PLoS One
September 2025
Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Volumetric modulated arc therapy (VMAT) for lung cancer involves complex multileaf collimator (MLC) motion, which increases sensitivity to interplay effects with tumour motion. Current dynamic conformal arc methods address this issue but may limit the achievable dose distribution optimisation compared with standard VMAT. This study examined the clinical utility of a VMAT technique with monitor unit limits (VMATliMU) to mimic conformal arc delivery and reduce interplay effects while maintaining plan quality.
View Article and Find Full Text PDFIEEE Trans Neural Netw Learn Syst
September 2025
In essence, reinforcement learning (RL) solves optimal control problem (OCP) by employing a neural network (NN) to fit the optimal policy from state to action. The accuracy of policy approximation is often very low in complex control tasks, leading to unsatisfactory control performance compared with online optimal controllers. A primary reason is that the landscape of value function is always not only rugged in most areas but also flat on the bottom, which damages the convergence to the minimum point.
View Article and Find Full Text PDFHum Genet
September 2025
College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China.
Recessive variants in TWNK cause syndromes arising from mitochondrial DNA (mtDNA) depletion. Hearing loss is the most prevalent manifestation in individuals with these disorders. However, the clinical and pathophysiological features have not been fully elucidated.
View Article and Find Full Text PDFCompr Rev Food Sci Food Saf
September 2025
Halal Products Research Institute, Universiti Putra Malaysia, Serdang, Malaysia.
The food system is under increased pressure because of the need for sustainability, greater food safety, and increasing need for protein sources. Grasshopper-based food products are becoming a new option. Products made from grasshoppers represent a sustainable and nutritious alternative to traditional livestock.
View Article and Find Full Text PDFFood Res Int
November 2025
College of Animal Sciences, Zhejiang University, Hangzhou, China; Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, China. Electronic address:
Cultured meat is an emerging field in future food production, employing interdisciplinary strategies that integrate the food industry, tissue engineering, and biotechnology to meet global food needs. Cultivating meat from stem cells is an increasingly recognized solution to address concerns associated with animal husbandry in terms of environment, health, and ethics. Despite significant advances, substantial technical challenges persist.
View Article and Find Full Text PDF