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Article Abstract
Unlabelled: Sleep deprivation is a serious problem that deteriorates the health, quality of life, and social productivity of affected individuals. Research on safe and effective plant-based materials should be performed to help alleviate sleep disorders. Turczaninow is a domestic plant in South Korea that has been used traditionally as a medicine to treat sleep disorders. The effects and mechanism of action of a Turczaninow root extract (PUTRE) prepared using hot water extraction were investigated. ICR mice were injected with pentobarbital to induce sleep. The PUTRE-treated groups had significantly ( < 0.05) decreased sleep latency and increased sleep time compared with the controls. When PUTRE was co-administered with adenosine antagonists (caffeine and 8-cyclopentyl-1,3-dipropylxanthine), it acted specifically on the adenosine A receptor, because its sleep-enhancing effect was counteracted by the adenosine antagonist. This is the first study to demonstrate that PUTRE can induce sleep through adenosine A receptor-specific agonist activity. Therefore, PUTRE is suggested as a valuable sleep-enhancing substance.
Supplementary Information: The online version contains supplementary material available at 10.1007/s10068-024-01663-4.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904018 | PMC |
| http://dx.doi.org/10.1007/s10068-024-01663-4 | DOI Listing |
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