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Purpose: X-ray-based patient-specific instrumentation (PSI) for total knee arthroplasty (TKA) is a new method for preoperative planning of TKA. This study presents the preliminary experiences with preoperative planning of TKA, comparing Zimmer Biomet's X-PSI™ with MRI-based planning for patient-specific instrumentation (PSI).
Methods: One high-volume experienced orthopedic surgeon modified and approved preoperative X-PSI™ and MRI-based PSI planning of 20 patients. Absolute differences in individual subjects of the planning by both modalities were evaluated for the following parameters: femoral- and tibial implant size, femoral resection (medial-distal, lateral-distal, medial-posterior, and lateral-posterior), tibial resection (medial and lateral), femoral flexion-extension angle, femoral- and tibial varus/valgus angle, posterior slope tibia, tibial rotation, and femoral- and tibial rotation.
Results: The planned implant size was within one size difference between X-PSI™ and MRI-based planning of the same patient in 95 % of cases for femoral implant size and 90 % of the cases for tibial implant size. Furthermore, femoral resection levels were more comparable between both imaging modalities, whereas more variation was seen between planned tibial resection levels.
Conclusion: This study presents a high agreement between X-PSI™ and MRI-based PSI in implant sizing and femoral resection levels, based on measurements within the same individuals, with greater variability observed in tibial resection. Further research is needed to validate and optimise PSI for TKA.
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http://dx.doi.org/10.1016/j.jcot.2025.102929 | DOI Listing |
JMIR Med Inform
September 2025
Department of Radiology, Air Force Medical Center, Air Force Medical University, Fucheng Road 30, Haidian District, Beijing, CN.
Background: Lateral malleolar avulsion fracture (LMAF) and subfibular ossicle (SFO) are distinct entities that both present as small bone fragments near the lateral malleolus on imaging, yet require different treatment strategies. Clinical and radiological differentiation is challenging, which can impede timely and precise management. On imaging, magnetic resonance imaging (MRI) is the diagnostic gold standard for differentiating LMAF from SFO, whereas radiological differentiation on computed tomography (CT) alone is challenging in routine practice.
View Article and Find Full Text PDFAbdom Radiol (NY)
September 2025
Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.
Objectives: The escalating global incidence of obesity, cardiometabolic disease and sarcopenia necessitates reliable body composition measurement tools. MRI-based assessment is the gold standard, with utility in both clinical and drug trial settings. This study aims to validate a new automated volumetric MRI method by comparing with manual ground truth, prior volumetric measurements, and against a new method for semi-automated single-slice area measurements.
View Article and Find Full Text PDFJ Obes
September 2025
School of Natural Sciences, University of Lincoln, Lincoln, UK.
To investigate the genetic determinants of fat distribution across anatomical sites and their implications for health outcomes. We analyzed neck-to-knee MRI data from the UK Biobank ( = 37,589) to measure fat at various locations and used Mendelian randomization to assess effects on 26 obesity-related diseases and 94 biomarkers from FinnGen and other consortia. We identified genetic loci associated with 10 fat depots: abdominal subcutaneous adipose tissue ( = 2 loci), thigh subcutaneous adipose tissue (25), thigh intermuscular adipose tissue (15), visceral adipose tissue (7), liver proton density fat fraction (PDFF) (8), pancreas PDFF (11), paraspinal adipose tissue (9), pelvic bone marrow fat (28), thigh bone marrow fat (27), and vertebrae bone marrow fat (5).
View Article and Find Full Text PDFMagn Reson Med
September 2025
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Purpose: Gadoxetic acid-enhanced hepatobiliary phase T-weighted (Tw) MRI is effective for the detection of focal liver lesions but lacks sufficient T contrast to distinguish benign from malignant lesions. Although the addition of T, diffusion, and dynamic contrast-enhanced Tw imaging improves lesion characterization, these methods often do not provide adequate spatial resolution to identify subcentimeter lesions. This work proposes a high-resolution, volumetric, free-breathing liver MRI method that produces colocalized fat-suppressed, variable Tw images from a single acquisition, thereby improving both lesion detection and characterization.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, China.
Purpose: To develop a magnetic resonance imaging (MRI)-based radiomics nomogram to predict lymphovascular space invasion (LVSI) status in patients with early-stage cervical adenocarcinoma (CAC).
Methods: Clinicopathological and MRI data from 310 patients with histopathologically confirmed early-stage CAC were retrospectively analyzed. Patients were divided into training (n = 186) and validation (n = 124) cohorts.