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http://dx.doi.org/10.1002/ecy.70063 | DOI Listing |
Physiol Rep
September 2025
Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
This study investigated the effects of fermentable fiber and polyphenol supplementation on mood and cognition following rapid ascent to simulated 4300 m. Healthy adults (n = 13, 21 ± 3 years) participated in a randomized, placebo-controlled crossover study consisting of three, 2-week phases separated by ≥1 week. Food products containing the fiber and polyphenol supplement or placebo were consumed during each phase.
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
September 2025
United States Army Research Institute of Environmental Medicine, Natick, MA, US.
Unlabelled: Insulin resistance has been associated with acute mountain sickness (AMS) risk, but the influence of active ascent is unclear.
Methods: Thirty-two unacclimatized Soldiers (23±4yr; 80±14 kg) were tested at baseline residence (BLR), hiked ~5 km (n=16) or were driven (n=16) to 4,300 m, and stayed for 4 days (~66 h). Venous blood was taken each morning at BLR and during high altitude (HA) exposure days 2-4 (HA2-4) and the evening on day 1 at HA (HA1).
Food Res Int
November 2025
Research Laboratory, Tibetan Hospital of Naqu, Tibetan, China. Electronic address:
Chronic high-altitude disease (CHAD) is primarily driven by oxidative damage and inflammation. Hydrogen-rich water (HRW) is a novel functional food with demonstrated antioxidant and anti-inflammatory properties. However, its potential effects on inflammation and oxidative stress in CHAD remain unexplored.
View Article and Find Full Text PDFJ Appl Physiol (1985)
September 2025
Department of Human Physiology and Nutrition, William J. Hybl Sport Medicine and Performance Center, University of Colorado Colorado Springs, Colorado Springs, CO, USA.
Chronic exposure to high altitude leads to increases in hemoglobin mass (Hbmass), which may improve exercise performance and decrease acute mountain sickness (AMS) symptoms. We evaluated the influence of intravenous iron or erythropoietin (EPO) treatment on Hbmass, exercise performance, and AMS during a 14-day exposure to 3094 m. Thirty-nine participants (12F) completed the study conducted in Eugene, Oregon (sea level (SL), 130 m) and Leadville, Colorado (3094 m).
View Article and Find Full Text PDFBiology (Basel)
July 2025
Department of Physiology, School of Medicine, Ankara University, Ankara 06230, Türkiye.
Hypoxia can adversely affect multiple organ systems. This study investigated the impact of intermittent hypoxia on serotonin levels and depression-like behaviors across distinct neuroanatomical regions. Sixteen adult female Wistar albino rats were divided into two groups: control ( = 8) and hypoxia ( = 8).
View Article and Find Full Text PDF