98%
921
2 minutes
20
This study introduces a novel method for gait analysis using a single inertial measurement unit placed on the sacrum. This method is valid not only on level ground but also on incline and decline conditions. The method leverages the "crackle" function, the third derivative of the sacral resultant acceleration, to identify right and left gait events. This approach is particularly effective in capturing the initial peak in acceleration data during foot impact with the ground, often overlooked by other methods. The study aimed to demonstrate the method's accuracy in identifying the right- and left-side impacts during level ground, incline, and decline runs across a range of speeds. Additionally, the algorithm was applied in outdoor running scenarios, where it performed very well, further validating its robustness and reliability. The results are compared with other existing methods to highlight the effectiveness of this approach.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894424 | PMC |
http://dx.doi.org/10.1017/wtc.2025.4 | DOI Listing |
Mol Divers
September 2025
Department of Biotechnology, National Institute of Technology Raipur, Raipur, Chhattisgarh, 492001, India.
Traditional drug discovery methods like high-throughput screening and molecular docking are slow and costly. This study introduces a machine learning framework to predict bioactivity (pIC₅₀) and identify key molecular properties and structural features for targeting Trypanothione reductase (TR), Protein kinase C theta (PKC-θ), and Cannabinoid receptor 1 (CB1) using data from the ChEMBL database. Molecular fingerprints, generated via PaDEL-Descriptor and RDKit, encoded structural features as binary vectors.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
September 2025
Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Targeted intraoperative radiotherapy (IORT) delivers a single dose of radiation to a fresh tumour bed immediately after lumpectomy, commonly used to treat early breast cancer (EBC). It is delivered during the same sitting, with improved patient compliance and better sparing of adjacent healthy tissue, compared to conventional adjuvant radiotherapy to the whole breast. The recently published 12-year results (median follow up of 8.
View Article and Find Full Text PDFJ Phys Chem Lett
September 2025
Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87106, United States.
Defects significantly influence charge transport in CHNHPbI (MAPbI) perovskite solar cells, particularly at interfaces. Using quantum dynamics simulation, we reveal a distinct interstitial iodine (I) defect behavior at different positions in the TiO/MAPbI system. In the perovskite bulk-like region, I exhibits high mobility and dissociates detrimental iodine trimers, facilitating small-to-large polaron transition and promoting shallow trap formation.
View Article and Find Full Text PDFA compact low-level RF (LLRF) control system based on RF system-on-chip (RFSoC) technology has been designed for the Advanced Concept Compact Electron Linear-accelerator (ACCEL) program, which has challenging requirements in both RF performance and size, weight, and power consumption (SWaP). The compact LLRF solution employs the direct RF sampling technique of RFSoC, which samples the RF signals directly without any analog upconversion and downconversion. Compared with the conventional heterodyne based architecture used for the LLRF system of a linear accelerator (LINAC), the elimination of analog mixers can significantly reduce the size and weight of the system, especially with LINAC requiring a larger number of RF channels.
View Article and Find Full Text PDFPest Manag Sci
September 2025
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Background: Peroxisomes are essential for the metabolism of very long-chain fatty acids (VLCFAs). Their biogenesis requires peroxins encoded by the PEX genes. While the significance of PEX14 has been established in the major rice pest the brown planthopper (Nilaparvata lugens), the role of PEX16 as a peroxisome biogenesis initiator remains uncharacterized in this pest.
View Article and Find Full Text PDF