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In February 1968, NASA purchased 400 antigravity ballpoint pens from the Fisher Pen Company for the Apollo Program to prevent potential harm to astronauts and equipment. Mechanical pencils previously used in microgravity posed risks like eye injuries from floating fragments penetrating the cornea. The cornea is vulnerable to abrasions, perforations, and chemical burns in such environments, affecting crewmembers aboard the International Space Station (ISS). While they undergo extensive training for emergency situations, there are inherent complexities when faced with eye injuries. In this challenging context, adapting available medications and leveraging emergency medical training is critical for addressing ocular injuries in a high-stakes environment. This paper explores ISS medications and management strategies for corneal injuries, highlighting the need to include effective medications and countermeasures in future ISS medical kits.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897398 | PMC |
http://dx.doi.org/10.1038/s41526-025-00462-3 | DOI Listing |
Ther Adv Ophthalmol
September 2025
Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, No. 23, Paidarfard St., Boostan 9 St., Pasdaran Avenue, Tehran 16666, Iran.
Scleral necrosis is a rare but severe complication caused by various etiologies. The main therapeutic approach is topical and systemic medical treatment. Surgical interventions may be indicated in unresponsive cases.
View Article and Find Full Text PDFFolia Med Cracov
December 2024
Department of Ophthalmology, Faculty of Medicine, Jagiellonian University Medical College, Kraków; Clinic of Ophthalmology and Ocular Oncology, University Hospital in Kraków, Poland.
Background: Eye injuries are a serious problem and may result in reduced visual acuity. The most common eye injuries include corneal damage, often involving the presence of a foreign body. OCT examination of the anterior segment - AS OCT - may be a valuable test in the diagnostics and follow-up of patients in whom the presence of a foreign body after eye trauma is suspected.
View Article and Find Full Text PDFBiomedicines
July 2025
Department of Ophthalmology, Prof. K. Gibiński University Clinical Center, Medical University of Silesia, 40-514 Katowice, Poland.
Post-traumatic corneal wounds that require suturing are quite common; they reduce corneal transparency and cause corneal distortion, leading to corneal astigmatism and higher-order aberrations. Excimer laser treatment can be a potentially beneficial intervention for such wounds. The observation aimed to evaluate the effectiveness of topography-guided custom ablation treatment (TCAT) in patients with corneal injuries.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
August 2025
Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri, United States.
Purpose: Open-field blast injury (OFBI) is a common cause of vision loss. This study investigated OFBI-induced changes in corneal transcriptome, signaling pathways, and protein-protein interactions using RNA sequencing (RNA-seq).
Methods: Sixty-four C57BL/6J mice were used.
Invest Ophthalmol Vis Sci
August 2025
Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China.
Purpose: This study investigates the role and primary mechanisms of platelet-derived growth factor-BB (PDGF-BB) in regulating corneal epithelial injury repair and nerve regeneration under diabetic conditions.
Methods: Type 1 diabetes was induced in C57BL/6 mice via streptozotocin injection. Platelet depletion was achieved using an anti-mouse GPIbα antibody.