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F fluorodeoxyglucose ([F]FDG) positron emission tomography/computed tomography (PET/CT) has established itself as a critical diagnostic tool in the evaluation of patients with bacteremia and fever of unknown origin (FUO), particularly following futile conventional investigations. These conditions are often challenging due to diverse underlying etiologies, including infections, inflammatory conditions and malignancies. PET/CT has the advantage of being a whole-body imaging technique with high sensitivity for detecting areas of increased metabolism often associated with infection or inflammation. In bacteremia, [F]FDG PET/CT can help identify metastatic infections, endocarditis, or abscesses which may be clinically silent and missed on conventional imaging. In FUO, it helps to identify underlying etiologies, directing treatment and management strategies. This review aims to describe the role of PET/CT imaging in these diverse clinical scenarios. Perspectives in the field, including novel equipment and tracers, will be briefly discussed.
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http://dx.doi.org/10.23736/S1824-4785.25.03618-0 | DOI Listing |
Infect Drug Resist
August 2025
Department of Clinical Laboratory, Sanmen People's Hospital, Sanmen, Zhejiang, People's Republic of China.
is usually a commensal of the oropharynx but can occasionally cause invasive disease. Herein, we report a rare case of bacteremia in a female with a 7-year history of aortic valve replacement (AVR), who presented with persistent fever but no respiratory symptoms or valvular vegetations. Blood cultures yielded , identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and confirmed via 16S rRNA sequencing.
View Article and Find Full Text PDFCureus
August 2025
Medical Mycology Research Center, Chiba University, Chiba, JPN.
species are known to cause disseminated infections in immunocompromised hosts, typically in patients with hematological malignancies undergoing chemotherapy and those with a history of antifungal use. This case report described a non-neutropenic 85-year-old male patient with fungemia following polymicrobial bacteremia. He presented with fever and disturbed consciousness and was admitted for sepsis (day 1).
View Article and Find Full Text PDFIDCases
August 2025
Department of Infectious Diseases, Japanese Red Cross Wakayama Medical Center, Japan.
Descending necrotizing mediastinitis (DNM), a severe complication arising from deep neck infection, developed in an obese 45-year-old Japanese male with diabetes. His condition was caused by a Group A Streptococcus (GAS) infection that arose following an earlier influenza A infection during a seasonal influenza outbreak. The patient had a good clinical course with surgical drainage and debridement with antibiotic treatment.
View Article and Find Full Text PDFNutr Clin Pract
August 2025
Section of Gastroenterology, Hepatology & Nutrition, Comer Children's Hospital, University of Chicago, Chicago, Illinois, USA.
Central line-associated bloodstream infections (CLABSI) are a significant cause of morbidity in children with intestinal failure (IF). Probiotic therapy is discouraged in patients with IF because of the increased risk of bacteremia with the probiotic organism. We report an unusual, previously undescribed, clinical presentation of a Lactobacillus-species CLABSI linked to yogurt consumption in a toddler with IF secondary to Megacystis-microcolon-intestinal hypoperistalsis syndrome.
View Article and Find Full Text PDFFront Microbiol
August 2025
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX, United States.
Bacteremia is a serious clinical condition in which pathogenic bacteria enter the bloodstream, putting patients at risk of septic shock and necessitating aggressive antibiotic treatment. Choosing the most effective antibiotic is crucial not only for resolving the infection but also for minimizing side effects, such as dysbiosis in the healthy microbiome and mitigating the evolution of antibiotic resistance. This requires rapid identification of the pathogen and antibiotic susceptibility testing, yet these processes are inherently slow in standard clinical microbiology labs due to reliance on growth-based assays.
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