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Objective: Child restraint systems (CRS) are essential in preventing injury during road traffic collisions, yet neonatal CRS discharge programmes are lacking worldwide. Trained healthcare providers have reported a lack of confidence in providing CRS advice during discharge. We aimed to study the barriers and facilitators in implementing a formal neonatal CRS discharge programme through the lens of healthcare providers.
Methods: We interviewed 10 allied health and nursing staff who received CRS training to find out the barriers and facilitators they perceived and experienced when engaging parents of newborns with CRS education prior to hospital discharge. Interviews were audio-recorded and transcribed verbatim. Inductive analysis sensitised by Billett's workplace-based learning theory was conducted using Braun and Clarke's thematic analysis.
Results: We constructed three themes. At the personal agency level, how participants viewed themselves and directed their cognition to the task affected their involvement in CRS education. At the social agency level, institutional and ward safety culture including the presence of ward CRS champions were powerful motivators for CRS education. Parental receptivity to CRS education was also important. Lastly, at the situational level, barriers to implementing a CRS discharge programme included factors such as competing duties at neonatal discharge.
Conclusion: Using a workplace learning theory, our study highlights that healthcare providers' commitment and delivery of CRS education at neonatal discharge is a complex interplay of personal agency, social agency and situational factors. Future efforts must address these factors to optimise the effectiveness of a neonatal CRS discharge programme.
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http://dx.doi.org/10.1136/ip-2024-045507 | DOI Listing |
J Biotechnol
September 2025
College of Engineering, China Agricultural University, Beijing 100083, China. Electronic address:
Cotton stalk (CTS) and corn stover (CRS) were pretreated using solid alkali (NaOH or Ca(OH)) assisted ball milling (BM). The physicochemical properties of the pretreated materials and their high-solid enzymatic hydrolysis performance were systematically investigated. The interaction between alkali and straw was synergistically enhanced by mechanical force generated during BM, achieving effective lignin removal.
View Article and Find Full Text PDFCytokine
September 2025
Department of Child and Adolescent Health, School of Public Health, Bengbu Medical University, No. 2600 Donghai Avenue Bengbu, Anhui, People's Republic of China; Department of Naval Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, Shanghai, PR China; Shanghai Key Labo
Purpose: This study aimed to elucidate the role of lateral hypothalamic area (LHA) Vglut2 neurons in stress-induced intestinal inflammation and to investigate the underlying mechanisms involving neuro-immune interactions. Specifically, we hypothesized that LHA Vglut2 neuron activation exacerbates intestinal inflammation via sympathetic-driven IL-1β and Cxcl1 signaling.
Methods: Transgenic mice (Vglut2-cre) and wild-type controls were subjected to chronic restraint stress (CRS).
J Dent Educ
September 2025
Division of Oral Diagnosis, Oral Medicine, and Oral Radiology, College of Dentistry, University of Kentucky, Lexington, Kentucky, USA.
Introduction: To compensate for inadequate clinical exposure to temporomandibular disorders (TMD) among dental students during predoctoral training, a virtual patient-based learning (VPBL) platform was developed for integration into the TMD predoctoral curriculum. This study tested the VPBL's content validity among 10 orofacial pain (OFP) experts responsible for TMD education at U.S.
View Article and Find Full Text PDFBiotechnol Appl Biochem
September 2025
Department of Pharmacy, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
The exact mechanism by which berberine alleviates depression remains unclear. In this study, we explored the relationship between the antidepressant effect of berberine and the microbiota-brain-gut axis. The levels of IL-1β, TNF-α, IL-6, corticosterone, serotonin, and brain-derived neurotrophic factor (BDNF) were quantified using enzyme-linked immunosorbent assays (ELISA) and Western blotting.
View Article and Find Full Text PDFCNS Drugs
September 2025
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Objective: To characterize multinational trends and patterns of opioid analgesic prescribing by sex and age.
Design, Setting, And Participants: We studied opioid analgesic prescribing from 2001 to 2019 with common protocol using population-based databases from eighteen countries and one special administrative region.
Main Outcome Measures: We measured opioid prescribing by geographical region, sex and age, estimating annual prevalent, incident, and nonincident opioid prescribing per 100 population with a 95% confidence interval (CI) and meta-analyzed the multinational and regional opioid prescribing with a random-effects model.