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A 23-year-old male presented with a 6-month history of left eyelid swelling and a 2-week history of headaches following a road traffic accident. Examination revealed left eye proptosis (23 mm vs. 19 mm on the right, normal 16 mm), limited abduction of the right eye, incomplete closure of the right upper eyelid, and right facial nerve weakness. No relative afferent pupillary defect (RAPD) was noted. Musculoskeletal ultrasound of the left eyelid identified an elongated subcutaneous cystic lesion with intense vascularity, indicative of a vascular lesion. CT of the facial bones with 3D reconstruction revealed bilateral proptosis, dilated superior ophthalmic veins, and enlarged cavernous sinuses, consistent with bilateral carotid-cavernous fistulas (CCFs). Otomastoiditis with facial nerve canal dehiscence was also noted, suggesting facial nerve involvement. MRI brain and orbit with gadolinium contrast demonstrated multiple dilated tortuous vascular structures communicating with the cavernous sinuses, dilated bilateral superior ophthalmic veins (left > right), and left eye proptosis, consistent with high-flow fistulas. High-flow characteristics were supported by early arterial filling of the cavernous sinuses, retrograde venous drainage, and superior ophthalmic vein dilation on MR angiogram. Bilateral CCFs are rare, typically resulting from trauma, and often present with proptosis, cranial nerve deficits, and orbital symptoms. Fundus examination revealed engorged retinal veins and mild optic disc swelling in the left eye, consistent with venous stasis. Endovascular surgery is the gold standard for treatment; however, this patient was managed symptomatically with analgesics due to financial constraints. This case demonstrates the importance of imaging in diagnosis and highlights the challenges of managing CCFs in resource-limited settings.
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http://dx.doi.org/10.1007/s13760-025-02756-5 | DOI Listing |
Eye (Lond)
September 2025
Department of Ophthalmology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, China.
Cortex
August 2025
University of Pittsburgh, Department of Ophthalmology, Pittsburgh PA 15219, USA; University of Pittsburgh, Department of Bioengineering, Pittsburgh PA 15213, USA.
The neural circuitry engaged in supporting eye movements has been well characterized, but fundamental questions remain about the necessity and sufficiency of the individual hemispheric contributions. To gain a better understanding of the neural correlates of oculomotor control, we measured horizontal smooth pursuit tracking behavior in 14 patients following childhood hemispherectomy. Relative to developmentally typical age-matched controls, patients exhibited a bilateral and asymmetric pursuit deficit with reduced ipsilesional but elevated contralesional eye speeds, and asymmetric accompanying 'catch up' saccades.
View Article and Find Full Text PDFOcul Immunol Inflamm
September 2025
Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
Purpose: To report a rare case of bilateral necrotising retinitis caused by a potentially novel human adenovirus D (HAdV-D) in a post-bone marrow transplant patient and to highlight the diagnostic challenges and therapeutic role of intravenous cidofovir, alongside a review of previously reported cases of human adenovirus (HAdV) retinitis.
Methods: Retrospective case report.
Results: A 60-year-old man with a history of acute myeloid leukaemia, in remission post-bone marrow transplant, presented with bilateral hypertensive granulomatous panuveitis and necrotising retinitis.
Infect Disord Drug Targets
August 2025
Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Introduction: Preseptal cellulitis, the most common periorbital cellulitis manifestation, is more common in children. The aim of this cross-sectional study was to analyze the diagnosis and treatment of preseptal cellulitis infections in patients admitted to Children's Medical Center, an Ira-nian referral hospital, between 2015 and 2019.
Methods: The demographic characteristics of patients, symptoms at admission, affected eye (unilat-eral/bilateral and right/left), the duration of symptoms and treatment, imaging findings, and the mi-crobial culture were recorded from patient history and medical files.
Unlabelled: Abnormal development of the intricate trabecular meshwork (TM) or Schlemm's canal (SC) structures in the eye can result in reduced aqueous humor fluid drainage and elevated intraocular pressure. If left untreated, these processes can lead to retinal ganglion cell loss, damage to the optic nerve, and infant-onset vision loss, termed congenital glaucoma. To identify gene expression important for development of these specialized aqueous humor outflow pathway (AHOP) structures, single-cell RNA sequencing was performed on rat AHOP tissues during three major periods of growth.
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