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Article Abstract
is a global agricultural pest which had developed resistance to different insecticides. The ATP-binding cassette (ABC) transporter plays an important role in insecticide resistance. However, ABC transporters' role and regulatory mechanism in mediating 's response to pyrethroids are unclear. In this study, we found that was significantly overexpressed in the pyrethroid-resistant strains of . Knockdown of significantly increased the susceptibility of to lambda-cyhalothrin and bifenthrin. Luciferase reporter gene analysis showed that miR-275 binds to the coding region and down-regulates its expression. Injection of miR-275 mimics significantly reduced expression and increased susceptibility to lambda-cyhalothrin and bifenthrin, while miR-275 inhibitor injection enhanced expression and increased tolerance to both insecticides. The results provide a theoretical basis for understanding the mechanism of miRNA-mediated pyrethroid resistance, and open up a new way for the development of miRNA-based biopesticides.
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| http://dx.doi.org/10.1021/acs.jafc.5c00388 | DOI Listing |
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