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This study assessed the effect of increasing assistance levels of a Pushrim-Activated Power-assisted Wheelchair (PAPAW) on the physiological and biomechanical demands in non-disabled participants propelling a manual wheelchair on an instrumented ergometer. This cross-sectional study included twenty-four non-disabled participants (aged years) who performed 4 submaximal trials of 4-minutes propulsion (at 1.11m/s and 0.21W/kg body mass resistance) using no, low, medium and high power-assist modes of a PAPAW in counterbalanced order. Physiological strain, in terms of metabolic energy expenditure, heart rate and perceived exertion, was examined, along with the force and velocity data from the wheelchair ergometer and PAPAW. Repeated measures ANOVA revealed that metabolic energy expenditure decreased significantly with each incremental step of assistance (no: W, low: W, medium: W, high: W, p ), accompanied by similar reductions in heart rate and perceived exertion. Similarly, work per push decreased with each step (no: J, low: J, medium: J, high: J, p ). This can be explained by reductions in propulsive forces, which reached a floor effect with no further reduction between medium and high assistance levels, and a decreased contact angle. The level of PAPAW assistance progressively reduces the metabolic and biomechanical demands of manual wheelchair propulsion, potentially lowering the risk of overuse injuries and enhancing participation in daily activities and society. Further research should explore the optimal assistance level that reduces strain while maintaining physical fitness during everyday mobility.
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http://dx.doi.org/10.1109/TNSRE.2025.3547052 | DOI Listing |
Nutr Metab Cardiovasc Dis
July 2025
Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, 16071, Spain; Universidad Autónoma de Chile, Facultad de Ciencias de la Salud, Talca, 1101, Chile.
Aims: Young people are consuming less healthy diets such as Mediterranean diet (MedDiet), which is associated with an increased risk of chronic diseases, including obesity. This systematic review aimed to synthesize the literature concerning the prevalence and trends of adherence to the (MedDiet) in a young Spanish population (aged 2-24 years) from 2004 to 2023.
Data Synthesis: The present review included observational studies and final assessments of longitudinal studies to assess the prevalence or trend in adherence to the MedDiet using the Mediterranean Diet Quality Index for Children and Adolescents (KIDMED) in three categories (low (≤3), medium (4-7), and high (≥8)).
Proc Biol Sci
September 2025
Department of Biology, Evolutionary Ecology and Infection Biology, Lund University, SE-223 62, Lund, Sweden.
Incubation temperature affects both growth and energy metabolism in birds after hatching. Changes in cellular mechanisms, including mitochondrial function, are a likely but unexplored explanation for these effects. To test whether temperature-dependent changes to mitochondria may link embryonic development to the post-natal phenotype, we incubated Japanese quail eggs at constant low (36.
View Article and Find Full Text PDFClin Gastroenterol Hepatol
September 2025
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University; State Key Laboratory of Digestive Health; National Clinical Research Center for Digestive Disease; Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices. Electronic address: shansh
Background & Aims: To investigate association between socioeconomic status (SES) and risk of incident irritable bowel syndrome (IBS), and mediating role of lifestyle factors.
Methods: Participants free of IBS at recruitment were included in this retrospective analysis of a prospectively collected cohort (N=353,790). SES was assessed through household income, education and employment status, with different patterns identified through latent class analysis.
J Steroid Biochem Mol Biol
September 2025
Department of Reproductive Medicine, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming City, Yunnan Province, 650000, China. Electronic address:
Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder characterized by ovarian dysfunction, with limited effective treatments. This study investigates the therapeutic effects and mechanisms of white kidney bean extract (WKBE) in a PCOS rat model. A PCOS model was established using letrozole, followed by intervention with varying doses of WKBE.
View Article and Find Full Text PDFNeurotoxicology
September 2025
Department of Otolaryngology Head and Neck Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China. Electronic address:
Gadolinium-based contrast agents (GBCAs) are widely used in systemic magnetic resonance imaging (MRI) and can be employed in otology to evaluate endolymphatic hydrops in patients with Ménière's disease. Given the heavy metal properties of gadolinium and its tendency to deposit in tissues, it is essential to assess its ototoxic risk. We evaluated the ototoxicity of gadodiamide using in vitro and in vivo models.
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