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Objective: Human pose estimation models can measure movement from videos at a large scale and low cost; however, open-source pose estimation models typically detect only sparse keypoints, which leads to inaccurate joint kinematics. OpenCap, a freely available service for researchers to measure movement from videos, mitigates this issue using a deep learning model-the marker enhancer-that transforms sparse video keypoints into dense anatomical markers. However, OpenCap performs poorly on movements not included in the training data. Here, we create a much larger and more diverse training dataset and develop a more accurate and generalizable marker enhancer.
Methods: We compiled marker-based motion capture data from 1176 subjects and synthesized 1433 hours of video keypoints and anatomical markers to train the marker enhancer. We evaluated its accuracy in computing kinematics using both benchmark movement videos and synthetic data representing unseen, diverse movements.
Results: The marker enhancer improved kinematic accuracy on benchmark movements (mean error: 4.1$^\circ$, max: 8.7$^\circ$) compared to using video keypoints (mean: 9.6$^\circ$, max: 43.1$^\circ$) and OpenCap's original enhancer (mean: 5.3$^\circ$, max: 11.5$^\circ$). It also better generalized to unseen, diverse movements (mean: 4.1$^\circ$, max: 6.7$^\circ$) than OpenCap's original enhancer (mean: 40.4$^\circ$, max: 252.0$^\circ$).
Conclusion: Our marker enhancer demonstrates both improved accuracy and generalizability across diverse movements.
Significance: We integrated the marker enhancer into OpenCap, thereby offering its thousands of users more accurate measurements across a broader range of movements.
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http://dx.doi.org/10.1109/TBME.2025.3530848 | DOI Listing |
ACS Biomater Sci Eng
September 2025
Materials Engineering, McGill university, Montreal H3A0C5, Canada.
Transcutaneous devices such as dental implants frequently fail due to infections at their interfaces with epithelial tissues. These infections are facilitated by the lack of integration between the devices and the surrounding soft tissues. This study aims to improve epithelial integration through surface modification of a transcutaneous implant material (polyetheretherketone (PEEK)).
View Article and Find Full Text PDFAnn Bot
September 2025
Royal Botanic Gardens, Kew, Richmond, Research department, Surrey, TW9 3AE, UK.
Background And Aims: Crop wild relatives (CWRs) are key resources for enhancing agricultural resilience, providing genetic traits that can improve pest resistance, abiotic stress tolerance, and nutritional composition in domesticated crops. Within the mustard family (Brassicaceae) this is especially significant in the Brassiceae tribe, which includes economically important genera for agriculture such as Brassica and Sinapis. However, while breeding programmes have historically focused on major crops within this tribe, the potential of their wild relatives, particularly for underutilised and minor crops, remains insufficiently explored.
View Article and Find Full Text PDFPLoS One
September 2025
Biobank of Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China.
Heart failure (HF) and lung cancer (LC) often coexist, yet their shared molecular mechanisms are unclear. We analyzed transcriptome data from the NCBI Gene Expression Omnibus (GEO) database (GSE141910, GSE57338) to identify 346 HF‑related differentially expressed genes (DEGs), then combined weighted gene co-expression network analysis (WGCNA) pinpointed 70 hub candidates. Further screening of these 70 hub candidates in TCGA lung cancer cohorts via LASSO, Random Forest, and multivariate Cox regression suggested CYP4B1 as the only independent prognostic marker.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Biomedical Data Intelligence, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Capturing the dynamic changes in patients' internal states as they approach death due to fatal diseases remains a major challenge in understanding individual pathologies and improving end-of-life care. However, existing methods primarily focus on specific test values or organ dysfunction markers, failing to provide a comprehensive view of the evolving internal state preceding death. To address this, we analyzed electronic health record (EHR) data from a single institution, including 8,976 cancer patients and 77 laboratory parameters, by constructing continuous mortality prediction models based on gradient-boosting decision trees and leveraging them for temporal analyses.
View Article and Find Full Text PDFJ Drug Target
September 2025
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Background: Chronic constriction injury (CCI) of the sciatic nerve induces neuropathic pain, inflammation, oxidative stress, and neurodegenerative changes, impairing sensory and emotional function. While curcumin is well recognized for its anti-inflammatory and neuroprotective properties, its therapeutic use is limited by poor bioavailability. Curcumin liposomal nanoparticles (CLNs) offer improved delivery and stability.
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