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http://dx.doi.org/10.1007/s10456-024-09964-2 | DOI Listing |
Bone
September 2025
Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA. Electronic address:
Pain in Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) remains poorly understood and inadequately managed due to uncertainties regarding clinical or biological drivers. This cross-sectional pilot study aimed to use plasma proteomics to identify markers that inform on molecular pathways associated with pain and emotional symptoms in FD/MAS. Seventeen individuals (15 females, 2 males), aged 16 to 63 years, with confirmed diagnoses of monostotic FD, polyostotic FD, or MAS participated in a single study visit conducted at Boston Children's Hospital and Massachusetts General Brigham.
View Article and Find Full Text PDFBiomedicines
May 2025
Institute of Chemistry and Geology, Oles Honchar Dnipro National University, 49000 Dnipro, Ukraine.
Liver disease is one of the most common medical problems in the world. The pharmacological correction of these pathologies includes the use of drugs with antioxidant and hepatoprotective action, among which there are natural and synthetic sulfur-containing compounds. However, many of these drugs have side effects, and their application does not always correspond to approaches in evidence-based medicine.
View Article and Find Full Text PDFAppl Spectrosc
May 2025
Leibniz Institute of Photonic Technology (Leibniz-IPHT), Albert-Einstein-Str. 9, 07745 Jena, Germany.
We present the first implementation of complex-valued classical least squares (CLS) regression in spectroscopy. Although the results indicate that complex-valued CLS does not outperform methods that utilize only the more suitable part of the complex refractive index spectra, it includes an error detection feature that enables a self-correction mechanism. This mechanism decreases the mean absolute error (MAE) to approximately 26% relative to using only the mid-infrared (MIR) absorption index () spectra for CLS, and to about 46% relative to using only the MIR refractive index () spectra of benzene-toluene mixtures.
View Article and Find Full Text PDFInt J Mol Sci
March 2025
Yunnan Key Laboratory of Screening and Research on Anti-Pathogenic Plant Resources from Western Yunnan (Cultivation), Dali University, Dali 671000, China.
Liver fibrosis is a pathological manifestation of chronic liver disease developing to the terminal stage, and there is a lack of effective therapeutic drugs in clinical practice. Scutellarin (SCU) is a flavonoid extracted from , which has significant anti-liver-fibrosis efficacy, but its mode of action remains incompletely understood. A liver fibrosis model was built with male Sprague Dawley rats induced with the disease by CCl to evaluate the therapeutic effect of drugs.
View Article and Find Full Text PDFAngiogenesis
February 2025
Department and Institute of Pharmacology, National Yang Ming Chiao Tung University, Taipei, Taiwan.