98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.jcin.2024.11.044 | DOI Listing |
Front Public Health
September 2025
Department of Respiratory Medicine, Xiamen TCM Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Xiamen, China.
Objective: Microplastics (MPs, 0.1-5000 μm) and nanoplastics (NPs, 0.001-0.
View Article and Find Full Text PDFChem Biomed Imaging
August 2025
National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Exp Mol Med
July 2025
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
CRISPR-based imaging technologies have emerged as powerful tools for visualizing specific genomic loci, providing groundbreaking insights into chromatin structure and dynamics. Here, in this Review, we discuss the development and recent advances in these techniques, highlighting key strategies such as signal amplification, background reduction, multiplexing and enhanced genomic resolution. By engineering Cas proteins and guide RNAs, and incorporating peptide and aptamer tags, researchers have remarkably improved the sensitivity, specificity and resolution of CRISPR-based imaging, enabling the detection of nonrepetitive genomic regions and single-nucleotide polymorphisms.
View Article and Find Full Text PDFJ Transl Med
July 2025
Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Rende, 87036, Italy.
Cancer cells orchestrate the surrounding tumor microenvironment (TME) to strike a fine balance between tissue regeneration providing them with nutrients, and tissue destruction triggered by immunogenic alarm signals. At steady state, the tenuous balance favors cancer growth. Therapies aimed at enhancing the immunogenic properties of cancer cells or the reacting immune responses can, however, revert the equilibrium to clear the host of cancer.
View Article and Find Full Text PDFACS Nano
July 2025
Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, P. R. China.
Developing high-capacity cathode materials is pivotal for advancing lithium-ion battery technology. While single-crystalline materials are widely regarded as structurally superior to polycrystalline counterparts, their presumed "perfect" crystallinity has recently been challenged by observations of intrinsic lattice defects and strain heterogeneity. Critically, the lack of direct experimental evidence for these defects and their role in degradation has hindered deeper understanding of single-crystalline cathode failure mechanisms.
View Article and Find Full Text PDF