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Despite increased calls for improved health equity, Black patients continue to experience worse pain and associated outcomes. Black patients are also offered fewer pain treatment options than White patients and report poorer quality communication with clinicians, including lower participation in shared decision-making. Comorbid depressive symptoms can impede effective pain management and participation in decision-making. The Equity Using Interventions for Pain and Depression (EQUIPD; NCT05695209) pilot study examined feasibility of a one-on-one coaching intervention, paired with a decision aid, to facilitate shared decision-making about evidence-based nonpharmacological pain treatments for Black patients with chronic musculoskeletal pain and symptoms of at least mild depression. We recruited and randomized 30 participants at a rate of 7.5 per month, with 90% retention at 3 months and 87% at 6 months. Intervention participation was high, with 94% of participants completing at least 3 of 4 coaching sessions. Fidelity was also high. Although not powered for effectiveness, most outcomes, including pain interference, depression, anxiety, patient engagement, and shared decision-making, improved, favoring the intervention, with effect sizes ranging from 0.30-0.75 at 3 months. Results indicate that EQUIPD holds promise as an intervention to support autonomy and shared decision-making for Black patients with chronic pain and elevated depressive symptoms. PERSPECTIVE: The EQUIPD intervention, which included one-on-one coaching combined with a decision aid to increase shared decision-making about nonpharmacological pain treatments, was feasible and shows promise in improving pain and related outcomes for Black patients with chronic musculoskeletal pain and depressive symptoms.
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http://dx.doi.org/10.1016/j.jpain.2025.105353 | DOI Listing |
Nat Genet
September 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Aberrant DNA methylation has been described in nearly all human cancers, yet its interplay with genomic alterations during tumor evolution is poorly understood. To explore this, we performed reduced representation bisulfite sequencing on 217 tumor and matched normal regions from 59 patients with non-small cell lung cancer from the TRACERx study to deconvolve tumor methylation. We developed two metrics for integrative evolutionary analysis with DNA and RNA sequencing data.
View Article and Find Full Text PDFHeart
September 2025
Kingston University, London, UK.
Importance/background: The 12-lead ECG is recommended in clinical guidelines for prehospital assessment of patients with suspected acute coronary syndrome (ACS) presenting to Emergency Medical Services (EMS).
Objectives: To determine prehospital ECG (PHECG) utilisation since UK national rollout of primary percutaneous coronary intervention, and whether this is associated with clinical outcomes in patients with ACS.
Design: Population-based, linked cohort study using Myocardial Ischaemia National Audit Project data from 1 January 2010 to 31 December 2017, related to patients with ACS conveyed by the EMS to hospital in England and Wales.
Ann N Y Acad Sci
September 2025
University of Toronto, Toronto, Ontario, Canada.
Neural oscillations in beta (13-30 Hz) and gamma (>30 Hz) frequency bands index a variety of sensorimotor and cognitive processes. To compare two rehabilitation regimens for chronic stroke patients with a hemiparetic hand, we randomly assigned them to either music-supported therapy or physiotherapy for 10 weeks. Previously, we reported the music group's improved motor speed, mood, well-being, and rhythm perception.
View Article and Find Full Text PDFHealth Serv Res
September 2025
Nova Southeastern University, Department of Psychology & Neuroscience, Fort Lauderdale, USA.
Objective: To examine the impact of patient-provider racial/ethnic concordance on adherence to a prescribed medication regimen in marginalized populations with a focus on health issues related to hypertension, heart condition/disease, elevated cholesterol, and diabetes.
Study Setting And Design: Applying the Andersen-Newman Behavioral Model of Health Service Use, we estimate multivariate linear models to analyze the number of prescriptions filled by patients within a calendar year using publicly available data from the Medical Expenditure Panel Survey (MEPS), a set of large-scale surveys of families and individuals, their medical providers, and employers across the United States.
Data Sources And Analytic Sample: Data from MEPS on patient race/ethnicity and provider race/ethnicity were collected from survey years 2007 to 2017 as well as data to control for demographic, socioeconomic, and health factors.
J Affect Disord
September 2025
Department of Psychology, Indiana University Indianapolis, 402 N. Blackford St., LD 100E, Indianapolis, IN, USA. Electronic address:
Background: Integrating digital mental health into collaborative care could address multiple mental health factors. To determine the longer-term effects of modernized collaborative care for depression on overlapping mental health factors, we analyzed data from the eIMPACT trial.
Methods: Primary care patients with depression and elevated cardiovascular disease risk (N = 216, Mage: 59 years, 78 % female, 50 % Black, 46 % with income <$10,000/year) were randomized to 12 months of the eIMPACT intervention (modernized collaborative care involving internet cognitive-behavioral therapy [iCBT], telephonic CBT, and/or select antidepressants) or usual primary care for depression.