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Background: Oral care is critical for preventing ventilator-associated pneumonia (VAP) in intensive care unit (ICU) patients. ICU nurses play a key role in delivering this care but often encounter challenges stemming from knowledge gaps and inconsistent practices.
Aim: To assess ICU nurses' knowledge, attitudes and practices (KAP) in oral care for VAP prevention and identify demographic factors influencing these variations using random forest analysis.
Study Design: A multi-centre cross-sectional study was conducted. Between April and June 2023, 291 ICU nurses from five ICUs across three public tertiary hospitals in Ganzhou City were surveyed using proportionate stratified sampling. Likert-scale questionnaires evaluated KAP, and statistical analyses, including t-tests, analysis of variance and random forest models, were used to determine demographic predictors of KAP scores.
Results: The average KAP scores were as follows: knowledge 27.34 (±4.53), attitudes 31.89 (±4.24), and practices 43.13 (±9.0). Significant predictors of KAP included academic titles, professional positions, gender, ICU tenure and department. Common barriers to effective oral care included lack of formal training, time constraints and limited resources.
Conclusions: ICU nurses demonstrate positive attitudes towards VAP prevention, but significant gaps in knowledge and practice remain. Targeted education, especially for less-experienced and lower qualified nurses, and standardized protocols are essential to improve adherence to oral care practices and reduce VAP incidence.
Relevance To Clinical Practice: The findings highlight the need for tailored educational interventions to address knowledge gaps, particularly among male, less-experienced and lower qualified nurses. Implementing standardized training protocols can enhance oral care practices, improve patient outcomes and reduce VAP incidence.
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http://dx.doi.org/10.1111/nicc.13289 | DOI Listing |
J Spinal Cord Med
September 2025
Department of Surgery, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
Study Design: A retrospective study with a crossover design.
Objectives: Maintaining mean arterial pressure (MAP) is crucial in the early management of SCI, yet the role of oral midodrine in this setting remains unclear. This study evaluates whether midodrine facilitates IV vasopressor weaning within 24 hours of initiation.
Clin Exp Rheumatol
September 2025
Rheumatology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Behçet's disease (BD) is a rare multisystemic vasculitis that significantly impacts patients' quality of life. Effective management of BD requires a patient-centred approach that empowers individuals to actively participate in their care. This work explores the importance of patient empowerment, adherence to treatment, and patient education in BD.
View Article and Find Full Text PDFJCI Insight
September 2025
Division of Nephrology, Boston University Chobanian & Avedisian School of Medicine, Boston, United States of America.
Background: Active vitamin D metabolites, including 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D), have potent immunomodulatory effects that attenuate acute kidney injury (AKI) in animal models.
Methods: We conducted a phase 2, randomized, double-blind, multiple-dose, 3-arm clinical trial comparing oral calcifediol (25D), calcitriol (1,25D), and placebo among 150 critically ill adult patients at high-risk of moderate-to-severe AKI. The primary endpoint was a hierarchical composite of death, kidney replacement therapy (KRT), and kidney injury (baseline-adjusted mean change in serum creatinine), each assessed within 7 days following enrollment using a rank-based procedure.
Neurol Res
September 2025
Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia, MO, USA.
Background: The benefits of rehabilitation in acute ischemic stroke patients following thrombectomy remain underexplored. We assessed which activities of daily living (ADLs) show the greatest improvement after goal-directed therapy in an inpatient rehabilitation setting.
Methods: We retrospectively analyzed pre- and post-rehabilitation functional assessments in 40 acute ischemic stroke patients treated with mechanical thrombectomy.
Tissue Eng Regen Med
September 2025
Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #505 BanPo-Dong, SeoCho-Gu, Seoul, 06591, Republic of Korea.
Background: Sjögren's syndrome (SS) is a chronic autoimmune disease delineated by excessive lymphocyte infiltration to the lacrimal or salivary glands, leading to dry eye and dry mouth. Exosomes secreted from mesenchymal stem cells (MSC) are known to have anti-inflammatory and tissue regeneration abilities. This study endeavored to demonstrate the effect of MSC-derived exosomes on the clinical parameter of dry eyes and associated pathology in SS mouse model.
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