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In the Department of Neuroscience in Clinical Neurological unit of our hospital, between 2020 and 2024, 58 adult patients were diagnosed with functional neurological disorder (FND). Out of these, 42 patients agreed to participate in a structured intervention consisting of 10 sessions of psychotherapy. This study aimed to investigate the demographic and clinical characteristics of the patient cohort, examine their reported symptoms, and evaluate the effectiveness and adherence to the psychotherapy program. The Affective Neuroscience Personality Scales (ANPS) were administered to assess the affective states of the patients, while the Shedler-Westen Assessment Procedure (SWAP-200) was used to evaluate their main personality style. A central objective of the research was to explore patterns or correlations between self-reported data from the patients and the evaluations completed by their therapists. This comparison sought to identify any alignment or discrepancies in the perception of symptoms and therapeutic progress, as measured by both the ANPS and SWAP-200 scales. The study's preliminary findings are reported to provide valuable insights into the impact of psychotherapeutic interventions for FND, including an understanding of the degree to which patient self-reports correspond with clinical assessments. These results will inform the optimization of treatment strategies and enhance patient outcomes by integrating patient feedback with clinical evaluations. The research contributes to the broader knowledge of FND management, emphasizing the importance of aligning patient and therapist perspectives in the therapeutic process.
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http://dx.doi.org/10.3389/fpsyg.2025.1506069 | DOI Listing |
Cereb Cortex
August 2025
Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Marseille 13005, France.
Over three decades, statistical parametric mapping has transformed neuroimaging from descriptive mapping to causal inference, placing generative models at the core of causal explanations for brain function. It inspired to a large degree The Virtual Brain, which builds subject-specific digital twins from multimodal data, enabling brain simulations and exploration. Both frameworks converge at parameter estimation, where model and data meet, providing the mathematical manifestation of cause-effect in pathophysiology.
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August 2025
The Clinical Hospital of Chengdu Brain Sciences Institute, University of Electronic Sciences and Technology of China (UESTC), 2006 Xiyuan Avenue, West Hi Tech Zone, 611731, Chengdu, China.
This commentary reflects three decades of interaction between the Cuban neuroinformatics tradition and the statistical parametric mapping (SPM) framework. From the early development of neurometrics in Cuba to global initiatives like the Global Brain Consortium, our trajectory has paralleled and intersected with that of SPM. We highlight shared commitments to generative modeling, Bayesian inference, and population-level brain mapping, as shaped through collaborations, workshops, and joint theoretical work with Karl Friston and his group.
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August 2025
Department of Psychology, University of Milano-Bicocca, Milan, Italy.
Semantic composition allows us to construct complex meanings (e.g., "dog house", "house dog") from simpler constituents ("dog", "house").
View Article and Find Full Text PDFProbiotics Antimicrob Proteins
September 2025
Operational Research Centre in Healthcare, Near East University, Nicosia, Cyprus.
Probiotics are live beneficial microorganisms that confer health benefits to the host when administered in adequate amounts, have gained considerable scientific and commercial interest for their ability to support gut health, strengthen immunity, and reduce disease risk. This review traces the genesis of probiotic science from its origins in traditional fermented foods to contemporary clinical applications, offering a conceptual understanding of its evolution. A clear distinction is drawn between endogenous probiotics, naturally resident in the human microbiome, and exogenous probiotics, introduced via dietary supplements and functional foods.
View Article and Find Full Text PDFMar Biotechnol (NY)
September 2025
Yazhou Bay Innovation Institute, Hainan Tropical Ocean University, Sanya, China.
Epinephelus tukula is an economically important aquaculture animal, and a major parent in grouper crossbreeding. To better preserve and exploit E. tukula germplasm resources, a core collection (containing 34 individuals derived from 10 genetic groups) was first constructed based on phenotypic growth traits and whole-genome resequencing (WGS) data.
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