The Complex Pathway of Conventional Investigations before the Diagnosis of Functional Motor Disorders.

Background: Functional motor disorder (FMD) is a diagnosis of inclusion based on the presence of positive signs on clinical examination, and only a few tests are validated as biomarkers for FMD identification.

Objectives: The aim of this study was to assess the relative frequency of different types of conventional instrumental investigations (such as magnetic resonance imaging/computed tomography [MRI/CT] scan, dopamine transporter single-photon emission computed tomography (DaT-SPECT), electroencephalography (EEG), neurophysiological tests, and other tests) in FMD patients before diagnosis and to identify the clinical and demographic features associated with their use.

Methods: Data were obtained from the Italian Registry of Functional Motor Disorders, a multicenter initiative involving patients with a diagnosis of clinically definite FMD.

Real-world safety comparison of liraglutide and semaglutide in weight management: Insights from European pharmacovigilance data.

Background: In recent years, the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), as liraglutide and semaglutide, for weight management has significantly risen. Even if these medications are effective, some concerns remain about their safety profiles, particularly regarding long-term adverse events (AEs). This study provides an evaluation of the safety profiles of liraglutide and semaglutide in a real-world setting.

Fast detection of , the causal agent of Citrus Mal Secco Disease, by real time loop-mediated isothermal amplification assay.

Citrus mal secco is a destructive tracheomycotic disease caused by mitosporic fungus Plenodomus tracheiphilus (Petri) Gruyter, Aveskamp, and Verkley, severely affecting cultivated citrus species, particularly lemon trees in the Mediterranean region. A novel diagnostic assay based on real-time loop-mediated isothermal amplification (LAMP) was developed for the rapid detection of P. tracheiphilus.

Association of semaglutide with less limb events in people with type 2 diabetes and peripheral artery disease or foot ulcers: An observational study comparing matched cohorts.

Aims: To compare major limb events in individuals with type 2 diabetes who initiated either injective or oral semaglutide versus other glucose-lowering therapies (GLT) in a real-world setting.

Materials And Methods: This was a single-centre retrospective observational study on new users of diabetes medications. Participants had to have type 2 diabetes and a diagnosis of peripheral artery disease (PAD) or foot ulcers.

Digital Health in Diabetes Care: A Narrative Review from Monitoring to the Management of Systemic and Neurologic Complications.

: Despite the recent advances in glucose-lowering therapy, achieving diabetes control remains challenging. With the advancing progress of innovative digital health technologies, management of diabetes is taking advantage from telehealth and telemedicine, which allow for remote assistance, virtual visits, and monitoring of diabetes-related parameters, and facilitate the exchange of documents and reports to support clinical decisions. We aim to provide an overview of the impact of telehealth and digital technologies on the care of people with diabetes, from therapeutic management to the assessment of complications.

Role of beta-blocker therapy on the sympathetic effects in stroke heart syndrome.

Background: Sympathetic activation, inflammation, and neuro-endocrine response after an ischemic stroke contribute to the development of the stroke heart syndrome (SHS). One marker of SHS is a troponin "rise and fall pattern" > 30%. Among the beta-blocker drugs, the β1 antagonist class has a selective effect on the heart against sympathetic neurotransmitters.

Unilateral Graves' disease: a case report with concomitant thyroid cancer and systematic review of literature.

Introduction: Unilateral uptake (i.e., increased radiotracer in one lobe) on a thyroid scan in a patient with Graves' disease (GD) is the distinctive feature of unilateral GD (UGD), representing a rare entity and variant of GD with few documented cases to date.

Lipoprotein-a and white matter abnormalities: predicting small vessel disease in young patients with ischemic cerebrovascular events.

Introduction: Post-stroke cognitive impairment (PSCI) affects 15-70% of ischemic stroke survivors, with vascular dementia contributing significantly to long-term disability. Lipoprotein(a) [Lp(a)] has emerged as a key risk factor for cardiovascular and cerebrovascular diseases, but its role in cerebral small vessel disease (cSVD) remains unclear. This study investigates the association between elevated Lp(a) levels and Fazekas scores (≥ 2), a marker of white matter hyperintensities (WMHs) indicative of cSVD, in young patients (< 65 years) with ischemic stroke or transient ischemic attack (TIA).

Liraglutide improves peripheral perfusion and markers of angiogenesis and inflammation in people with type 2 diabetes and peripheral artery disease: An 18-month follow-up of a randomized clinical trial.

Aims: In a six-month randomized clinical trial, improved peripheral perfusion has been shown with liraglutide, associated with favourable vascular effects in people with type 2 diabetes and peripheral artery disease (PAD). We aimed to evaluate the durability of these benefits and to elucidate some mechanisms underlying liraglutide's effect over an 18-month follow-up.

Methods: STARDUST was a randomized clinical trial which compared liraglutide up to 1.

Psychological assessment and support in functional neurological disorder: a longitudinal study.

In the Department of Neuroscience in Clinical Neurological unit of our hospital, between 2020 and 2024, 58 adult patients were diagnosed with functional neurological disorder (FND). Out of these, 42 patients agreed to participate in a structured intervention consisting of 10 sessions of psychotherapy. This study aimed to investigate the demographic and clinical characteristics of the patient cohort, examine their reported symptoms, and evaluate the effectiveness and adherence to the psychotherapy program.

Effectiveness of CT perfusion in posterior circulation stroke: evaluation of perfusion abnormalities and associated clinical signs.

Purpose: Acute posterior circulation stroke (PCS) is characterized by often non-specific clinical signs, with neuroimaging playing a pivotal role in assessment in the emergency setting. The aim of this study was to investigate the effectiveness of CT Perfusion (CTP) maps in detecting acute PCS and to identify clinical factors associated with perfusion abnormalities.

Methods: We retrospectively analyzed clinical and radiological data of consecutive patients with acute PCS admitted to our Stroke Unit that underwent CTP.

Prevalence and Management of Complications of Laser Ablation for Benign Thyroid Nodules.

Context: Percutaneous laser ablation (LA) is today regarded as a valuable therapy for symptomatic, benign solid (noncystic) thyroid nodules (STNs).

Objective: We assessed the prevalence of complications from LA for benign and STNs and their management.

Methods: We conducted a systematic review with meta-analysis of data from published studies on LA of STNs, in addition to author institutions.

Changes in cerebrovascular reactivity as a marker of cognitive impairment risk: a transcranial Doppler study.

Introduction: Post-stroke cognitive impairment (PSCI) and dementia affect short- and long-term outcome after stroke and can persist even after recover from a physical handicap. The process underlying PSCI is not yet fully understood. Transcranial Doppler ultrasound (TCD) is a feasible method to investigate cerebrovascular aging or dementia, through the pulsatility index (PI), the cerebrovascular reactivity (e.

Sexual dysfunctions in inflammatory bowel disease: role of Mediterranean diet and quality of life.

Background: Dietary factors and chronic gastrointestinal diseases are frequent determinants of sexual dysfunctions (SD). Whether inflammatory bowel diseases (IBD) are associated with SD is not well known as well as the role of diet and quality of life (QoL).

Objectives: To evaluate the prevalence of SD in a cohort of IBD patients and assess the role of clinical-demographic variables, adherence to Mediterranean diet (MD) and QoL.

Clinical characteristics and management of functional neurological disorders (FND) mimicking stroke in emergency settings: a functional stroke mimic cases.

Background: FNDs mimicking a stroke represent a growing challenge in the emergency department (ED). A comprehensive diagnostic approach involving clinical evaluation and neuroimaging is essential to differentiate stroke from mimics. The safety profile of thrombolysis justifies its use where FNDs cannot be ruled out.

Investigation of Aberrant Basaloid Cells in a Rat Model of Lung Fibrosis.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease (ILD) whose cause and pathogenesis are not yet well understood. Until now, no animal model of lung fibrosis succeeds in recapitulating all IPF features, thus the use of different rodent models is essential for the evaluation and development of new effective pharmacological treatments. Recently, the alveolar epithelial dysfunction has been emphasized in the etiopathogenesis context of IPF.

Stroke heart injury: the effect of cerebral reperfusion treatment. A 3-year retrospective study.

Background: Cardiac involvement following an acute stroke (Stroke Heart Syndrome-SHS) is an established complication and it is linked to the involvement of sympathetic activation, inflammation, and neuro-endocrine response. Troponin "rise and fall pattern" > 30% is one marker of SHS. The aim of this study was to evaluate the role of reperfusion treatments in the prevention/pathogenesis of SHS with different stroke sizes and locations (OCSP classification).