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http://dx.doi.org/10.1038/s41433-025-03708-2 | DOI Listing |
ISA Trans
September 2025
School of Mechatronic Engineering, Jiangsu Normal University, Xuzhou 221116, China. Electronic address:
Multi-arm rock drilling robots frequently encounter challenges in extreme environments, such as tunnels, where they are subjected to high-frequency impact loads, multi-degree-of-freedom motion coupling, and large-range motion control vibrations. First, we propose a collision-free path planning method that combines an improved genetic algorithm (IGA) and an improved artificial potential field method. This method is based on the kinematic model of the rock drilling robot.
View Article and Find Full Text PDFJ Med Microbiol
September 2025
Alberta Precision Laboratories Public Health Lab, Edmonton, Alberta, Canada.
For thousands of years, parasitic infections have represented a constant challenge to human health. Despite constant progress in science and medicine, the challenge has remained mostly unchanged over the years, partly due to the vast complexity of the host-parasite-environment relationships. Over the last century, our approaches to these challenges have evolved through considerable advances in science and technology, offering new and better solutions.
View Article and Find Full Text PDFFront Syst Biol
August 2025
Minutia.AI Pte. Ltd., Singapore, Singapore.
A representation of the cause-effect mechanism is needed to enable artificial intelligence to represent how the world works. Bayesian Networks (BNs) have proven to be an effective and versatile tool for this task. BNs require constructing a structure of dependencies among variables and learning the parameters that govern these relationships.
View Article and Find Full Text PDFFood Res Int
November 2025
Medical School of Nantong University, Nantong 226001, China. Electronic address:
Food nutrition and safety are fundamental to the food industry, and the development of appropriate research models is crucial. Unlike traditional animal models, the innovative organoid/organ-on-a-chip model possess distinct human-like characteristics and genomic stability, which have garnered significant attention in food research. In this review, we conduct a comparative analysis between organoids and traditional animal and 2D cell models.
View Article and Find Full Text PDFAdv Mater
September 2025
Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.
Nanomedicine has shown remarkable promise in advancing tumor imaging and therapy through its ability to achieve targeted delivery, precision imaging, and therapeutic efficacy. However, translating these preclinical successes into clinical practice remains fraught with challenges, including inconsistent tumor targeting, off-target organ accumulation, and a lack of comprehensive understanding of in vivo behavior of nanomedicines. In this perspective, the current state of nanomedicine research is critically analyzed, emphasizing the translational bottlenecks and offering a forward-looking view on potential solutions.
View Article and Find Full Text PDF