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| http://dx.doi.org/10.1016/j.jocn.2025.111117 | DOI Listing |
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Systematic analyses uncover plasma proteins linked to incident cardiovascular diseases.
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Cardiovascular disease (CVD) research is hindered by limited comprehensive analyses of plasma proteome across disease subtypes. Here, we systematically investigated the associations between plasma proteins and cardiovascular outcomes in 53,026 UK Biobank participants over a 14-year follow-up. Association analyses identified 3,089 significant associations involving 892 unique protein analytes across 13 CVD outcomes.
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Canids originally evolved in North America, presenting a compelling story of shifting climates, paleogeographies, and both successes and failures in adapting to these changes. Species evolve-new ones arrive on the scene and established ones become extinct. The dire wolf (Aenocyon dirus) is one of the most legendary of the extinct canids and is the most basal member of the crown group of large dogs (Canina) that includes the extant gray wolf (Canis lupus).
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