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The factor structure of the Concussion Clinical Profiles Screen (CP Screen) has not been empirically evaluated. In this study, 323 patients (59% male; 74% sport-related) completed CP Screen, ImPACT, and Vestibular/Ocular-Motor Screening (VOMS) at initial clinical visit within 30 days of concussion (±/-6.10 days). A second-order model best fit the data, with cognitive-fatigue, migraine, and ocular factors comprising a second-order factor. Loadings were all significant/substantial. Vestibular, ocular, and cognitive-fatigue factors all significantly (βs = .15-.44 ps ≤ .01) predicted assessments in similar domains, supporting concurrent validity. This study provides initial psychometric support for the structure of the CP-screen.
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http://dx.doi.org/10.1080/87565641.2025.2464738 | DOI Listing |
PLoS One
September 2025
Biobank of Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China.
Heart failure (HF) and lung cancer (LC) often coexist, yet their shared molecular mechanisms are unclear. We analyzed transcriptome data from the NCBI Gene Expression Omnibus (GEO) database (GSE141910, GSE57338) to identify 346 HF‑related differentially expressed genes (DEGs), then combined weighted gene co-expression network analysis (WGCNA) pinpointed 70 hub candidates. Further screening of these 70 hub candidates in TCGA lung cancer cohorts via LASSO, Random Forest, and multivariate Cox regression suggested CYP4B1 as the only independent prognostic marker.
View Article and Find Full Text PDFJ Alzheimers Dis
September 2025
The Framingham Heart Study, Framingham, MA, USA.
BackgroundWomen have a higher risk of dementia than men. Reproductive factors may be implicated.ObjectiveDetermine the association between reproductive factors (earlier menarche, later menopause, longer reproductive lifespan (RLS), post-menopausal hormone replacement therapy [pmHRT] use, and serum estradiol/estrone) and neurocognitive and neuroimaging markers of brain aging and incident dementia in cognitively healthy women.
View Article and Find Full Text PDFEur J Sport Sci
October 2025
Department of Intervention Research in Exercise Training, German Sport University Cologne, Cologne, Germany.
The concurrent validity of lactate thresholds (LT1, LT2) and between-day reliability data from the rowing-specific heart rate variability (HRV)-based thresholds (HRVT) were examined. Thus, 21 rowers (19.6 ± 2.
View Article and Find Full Text PDFFood Res Int
November 2025
School of Food and Biological Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China; Shaanxi Research Institute of Agricultural Products Processing Technology, Xi'an 710021, China. Electronic address:
Goat milk is prized for its nutritional value, but the illegal addition of δ-decanolactone to enhance flavor poses risks to product integrity and safety. This study employed a tripartite multi-omics framework integrating metabolomics, lipidomics, and proteomics, combined with FTIR and CLSM to systematically elucidate the multifaceted effects of δ-decanolactone on goat milk. Chemometric and bioinformatic pipelines identified dysregulated molecules and pathways, while molecular docking validated interactions with key targets.
View Article and Find Full Text PDFNat Methods
September 2025
Department of Radiology, Michigan State University, East Lansing, MI, USA.
Concurrent recording of electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) signals reveals cross-scale neurovascular dynamics crucial for explaining fundamental linkages between function and behaviors. However, MRI scanners generate artifacts for EEG detection. Despite existing denoising methods, cabled connections to EEG receivers are susceptible to environmental fluctuations inside MRI scanners, creating baseline drifts that complicate EEG signal retrieval from the noisy background.
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