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Background: The occurrence of arrhythmias as a complication of Kawasaki disease (KD) is extremely rare. Moreover, previous literature showed a low incidence of arrhythmias during the acute phase of KD, and the majority occurred in the subacute and chronic phases. To date, we have found only 17 sporadically reported global cases in the available literature.
Case Presentation: We present the first documented case of an infant with KD complicated with supraventricular tachycardia (Atrioventricular reentrant tachycardia) during the acute phase. The arrhythmia resolved promptly after the combination therapy of intravenous Immunoglobulin (IVIG) and steroids during the acute phase since the inflammation subsided. Additionally, we conducted a review and summary of cases involving KD-related arrhythmias.
Conclusions: KD rarely causes arrhythmias, which might be associated with myocarditis and myocardial ischemia attributed to scar formation and/or excessive inflammatory factors damaging the conduction system. Strengthening the early identification and management of complications in patients with KD and personalized follow-up strategies for high-risk children during the chronic phase can enhance patients' prognosis.
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http://dx.doi.org/10.1186/s12969-025-01061-y | DOI Listing |
Immunol Invest
September 2025
Department of Function, Affiliated Wuxi Fifth Hospital of Jiangnan University, Wuxi, China.
Objective: This study aims to elucidate how butyrate, a short-chain fatty acid, regulates the Treg/Th17 balance in ulcerative colitis (UC) via the cAMP-PKA/mTOR signaling pathway, offering novel treatment strategies.
Methods: Dextran sulfate sodium (DSS) was used to induce ulcerative colitis in a mouse model. Various butyrate dosages were administered to the mice.
Neurol Med Chir (Tokyo)
September 2025
Department of Neurosurgery, Kurume University School of Medicine.
Currently, there is no effective treatment for elevated intracranial pressure in the acute phase of subarachnoid hemorrhage. Recently, we developed "step-down infusion of barbiturate," a therapeutic strategy for severe traumatic brain injury, which decreased intracranial pressure and significantly reduced mortality without serious side effects. This study aimed to examine the efficacy of step-down infusion of barbiturate in patients with severe subarachnoid hemorrhage.
View Article and Find Full Text PDFAm J Pharm Educ
September 2025
Touro College of Pharmacy, New York, NY.
Cancer rates are on the rise and new treatments are helping people live longer with cancer, yet the questions remains: when does one consider themselves a cancer survivor and what direction does one's career need to take when diagnosed with cancer? This commentary explores how mentoring can support working individuals, such as pharmacy faculty and staff, across the three distinct phases of cancer survivorship, (1) the acute phase including testing, diagnosis, staging, and treatment; (2) the post-treatment survival phase; and (3) the permanent phase of disease-free survival. While career mentoring programs may exist for pharmacy faculty and staff across various pharmacy practice settings, there is a notable lack of structured mentoring programs available for those faculty and staff navigating a cancer diagnosis, especially as mentoring needs shift throughout these three cancer survivorship phases. Thoughtful mentoring and support can significantly enhance the personal and professional quality of life for individuals with cancer.
View Article and Find Full Text PDFEpilepsy Behav
September 2025
Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Einstein Center for Neurosciences (ECN), Charité - Universitätsmedizin Berlin, Germany. Electronic address:
Reactive astrogliosis and microgliosis are hallmarks of various central nervous system (CNS) diseases, including epilepsy. Both are observed following seizures in various models of epilepsy. We conducted a systematic meta-analysis to synthesize current knowledge on reactive astrogliosis and microgliosis in animal models involving experimentally induced seizures using a multilevel approach to analyze 260 comparisons from 52 studies.
View Article and Find Full Text PDFEur Radiol
September 2025
Department of Anesthesiology and Intensive Care Medicine, University Hospital Leipzig, Liebigstr. 20, 04103, Leipzig, Germany.
Objectives: Contrast extravasation on imaging studies is a clinical surrogate for bleeding severity. However, the prognostic relevance of this imaging sign needs to be evaluated. The aim of this study was to analyze the impact of contrast extravasation defined by computed tomography (CT) and angiography on massive transfusion and 30-day mortality in patients with acute bleeding undergoing transarterial embolization (TAE).
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