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Background And Aims: Peripheral nerve block (PNB) is commonly used, but there is a lack of data on its effectiveness and safety in the clinic. Therefore, anesthesiologists have limited insight into how they are faring in terms of both safety and efficacy. Additionally, No PNB registry is recorded in IRAN. Herein, we reveal how a hospital might use information gathered in a hospital registry of PNB outcomes to guide future quality enhancement efforts.
Method: This was an observational, prospective, and unicenter study of all peripheral nerve blocks done in the operating room since December 22, 2022. After studying the data collected by the existing registries worldwide, the anesthesiology research center at Taleghani Hospital developed a questionnaire that incorporated the varying parameters set forth by earlier research and registries. Parameters were documented for each patient.
Results: A total of 105 patients, were accrued from December 22, 2022, to July 23, 2023. The brachial plexus blocks namely axillary, infraclavicular, and popliteal blocks were the most frequently used PNBs, respectively. The indications that generated the greatest demand for PNBs were upper limb fractures, I&D, and amputation, respectively. 82.9% of blocks were conducted while patients were sedated employing systemic administration of sedatives. In this registry, there were no deaths or complications with sequelae. The median duration of hospitalization following admission to the hospital was 3 days. The mean patient satisfaction score was 9.46 out of 10.
Conclusion: Our analysis demonstrates the effectiveness, safety, and feasibility of peripheral nerve blocks in preoperative anesthesia. It is recommended to continue the registry and conduct additional studies to enhance our understanding of this procedure.
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http://dx.doi.org/10.3389/fmed.2025.1486300 | DOI Listing |
Ann Afr Med
September 2025
Department of Anaesthesiology, Kasturba Medical College Mangalore Manipal Academy of Higher Education, Manipal, India.
Background: Regional anesthesia techniques, such as unilateral spinal anesthesia and peripheral nerve blocks, are essential components of multimodal analgesia. Nonetheless, "rebound pain," an abrupt increase in nociceptive intensity following the cessation of the block, is inadequately defined and may compromise patient satisfaction and functional recovery.
Aims And Objectives: This study aimed to compare postoperative pain profiles, the incidence of rebound pain, and patient satisfaction following popliteal sciatic nerve block versus unilateral spinal anesthesia in elective foot surgeries.
Elife
September 2025
Department of Neuroscience, Washington University School of Medicine, St Louis, United States.
Peripheral sensory neurons regenerate their axons after injury to regain function, but this ability declines with age. The mechanisms behind this decline are not fully understood. While excessive production of endothelin 1 (ET-1), a potent vasoconstrictor, is linked to many diseases that increase with age, the role of ET-1 and its receptors in axon regeneration is unknown.
View Article and Find Full Text PDFAnn Clin Transl Neurol
September 2025
Department of Neurology, Brain Centre Utrecht, University Medical Centre Utrecht, Utrecht, the Netherlands.
Objective: We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients.
Methods: We included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9) and 24 were noncarriers (C9). In addition, 11 C9 and 110 C9 ALS patients and 50 healthy controls participated.
Medicine (Baltimore)
September 2025
Department of Anesthesiology, The First Affiliated Hospital of Traditional Chinese Medicine of Chengdu Medical College, XinDu Hospital of Traditional Chinese Medicine, Chengdu, China.
Background: With ultrasound-guided nerve block technology being increasingly used in hip surgery, the choice between fascia iliaca block (FIB) and lumbar plexus block (LPB) is still inconclusive. This study aims to evaluate the advantages and disadvantages of FIB and LPB in hip surgery.
Methods: PubMed, Web of Science, Cochrane Library, Embase, and CNKI were searched from inception to October 4, 2022.
Exp Clin Endocrinol Diabetes
August 2025
Department of Endocrinology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China.
Painful diabetic neuropathy (PDN), a severe microvascular complication of diabetes, is closely associated with neuroinflammation. This study aimed to investigate the mechanism of circ_0002590 in neuroinflammation associated with PDN.The Schwann cells (HEI193) were treated with high glucose (HG, 150 mM) to simulate the diabetic microenvironment.
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