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Background: Diagnosing cervical radiculopathy with root anomalies is difficult, as cervical nerve root anomalies are rare. Here, the authors report the rare case of a conjoined nerve root variant confirmed using full endoscopic cervical foraminotomy (FECF).
Observations: A 40-year-old female presented with painful numbness and paresis in the right upper limb. Physical examination revealed multiple radiculopathies in the C6 and C7 nerve roots. However, magnetic resonance imaging and computed tomography did not reveal any lesions explaining the right C7 radiculopathy. Furthermore, the right C6 root block injection had no effect, whereas the right C7 root block injection was extremely effective. FECF revealed a conjoined nerve root variant in the right C6-7 intervertebral foramen.
Lessons: The study revealed that single nerve root block injections can be useful for pain relief as well as diagnosis of the affected level. Although the current case is rare, the report revealed that a lesion at a single intervertebral foramen can cause multiple radiculopathies. The study also highlighted the importance of careful examination of the clinical symptoms and the limitations of imaging tools. https://thejns.org/doi/10.3171/CASE24752.
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http://dx.doi.org/10.3171/CASE24752 | DOI Listing |
World Neurosurg
September 2025
Department of Neurosurgery, Independent Public Specialist Western Hospital John Paul II in Grodzisk Mazowiecki, Daleka 11, 05-825, Grodzisk Mazowiecki, PL. Electronic address:
Introduction: Anterior cervical discectomy and fusion (ACDF) is a common surgical procedure used to treat herniated discs, degenerative disc disease, and nerve root compression in the cervical spine. This systematic literature review aims to analyze the available literature on the incidence, risk factors, clinical considerations, and available therapies for spinal epidural hematoma (SEH) following ACDF.
Methods: A systematic search was conducted in PubMed, Google Scholar, and Embase from database inception to June 18, 2025, following the PRISMA guidelines.
J Autoimmun
September 2025
Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; Cellular Genomics Futures Institute & School of Biomedical Sciences, UNSW Sydney, Australia. Electronic address:
Background: In autoimmune disease it is not understood how self-reactive B cells escape immune tolerance checkpoints to produce pathogenic autoantibodies.
Objective: In patients with demyelinating polyneuropathy caused by IgM autoantibodies against myelin associated glycoprotein (MAG) and the sulphated trisaccharide CD57, we aimed to test the hypothesis that B cells making the autoantibody escaped tolerance by acquiring lymphoma driver somatic mutations.
Methods: Deep single-cell RNA, DNA, flow cytometric and antibody specificity analysis of blood from three patients with MAG neuropathy.
Neuropharmacology
September 2025
Metabolic Disorders and Neuroscience Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Sciences Pilani, Hyderabad Campus, Hyderabad, India. Electronic address:
Neuroinflammation is vital in vincristine-induced peripheral neuropathy (VIPN). Locally infiltrated macrophages polarize to pro-inflammatory M1-type, release inflammatory cytokines, and contribute to neuropathic pain. Histone deacetylase 3 (HDAC3) regulates macrophage polarization.
View Article and Find Full Text PDFPain Med
September 2025
Gazi University Faculty of Medicine, Department of Neurology, Ankara, Turkey.
Background: Dorsal root ganglion (DRG) pulsed radiofrequency (PRF) is a minimally invasive neuromodulation technique used for the management of chronic radicular pain. While its analgesic effects are well-documented, its impact on sensorimotor integration at the cortical level remains unclear. This study aimed to investigate whether DRG PRF modulates sensorimotor integration via the cholinergic system using the Short-Latency Afferent Inhibition (SAI) paradigm.
View Article and Find Full Text PDFAnn Surg Oncol
September 2025
Department of Colorectal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Background: The ligation of the inferior mesenteric artery (IMA) is the primary procedure during surgeries of the left colon, sigmoid colon, and rectal cancer. Despite the ongoing debate on high or low ligation of the IMA, high ligation (HL) is now preferred by most of the surgeons. However, there is still a lack of consistency in the exact position of HL among surgical videos or introductions presented by different teams, causing confusion to new learners.
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