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Background: Musculoskeletal soft tissue tumors represent a complex category of neoplasms with varied biological behavior and prognosis. Accurate diagnosis and characterization of these tumors are essential for appropriate management. Magnetic Resonance Imaging (MRI) and Ultrasound (US) are commonly employed imaging modalities for evaluating soft tissue masses.
Materials And Methods: This comparative study included 100 patients with clinically suspected musculoskeletal soft tissue tumors. Patients underwent both MRI and Ultrasound evaluations. The imaging findings were compared with histopathological results, which served as the gold standard. Diagnostic parameters including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for both MRI and Ultrasound.
Results: Out of 100 patients, 70 cases were diagnosed as malignant and 30 as benign on histopathology. MRI correctly identified 68 malignant and 28 benign cases, with a sensitivity of 97.1%, specificity of 93.3%, PPV of 95.8%, and NPV of 96.6%. Ultrasound accurately diagnosed 60 malignant and 25 benign cases, with a sensitivity of 85.7%, specificity of 83.3%, PPV of 90.9%, and NPV of 76.9%. MRI demonstrated superior diagnostic accuracy compared to Ultrasound, particularly in identifying malignancies.
Conclusion: MRI is a more reliable imaging modality compared to Ultrasound for diagnosing musculoskeletal soft tissue tumors, particularly in distinguishing between benign and malignant lesions. The higher sensitivity and specificity of MRI suggest its preference as the first-line imaging technique in clinical practice for these conditions.
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http://dx.doi.org/10.4103/jpbs.jpbs_1113_24 | DOI Listing |
J Cancer Res Clin Oncol
September 2025
Department of Surgery, Mannheim School of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Purpose: The study aims to compare the treatment recommendations generated by four leading large language models (LLMs) with those from 21 sarcoma centers' multidisciplinary tumor boards (MTBs) of the sarcoma ring trial in managing complex soft tissue sarcoma (STS) cases.
Methods: We simulated STS-MTBs using four LLMs-Llama 3.2-vison: 90b, Claude 3.
J Hum Genet
September 2025
Division of Integrative Genomics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Comprehensive genomic profiling (CGP) expands treatment options for solid tumor patients and identifies hereditary cancers. However, in Japan, confirmatory tests have been conducted in only 31.6% of patients with presumed germline pathogenic variants (GPVs) detected through tumor-only testing.
View Article and Find Full Text PDFActa Ortop Mex
September 2025
Servicio de Cirugía Ortopédica y Traumatología, Hospital Clínico Universitario-Malvarrosa. Valencia, España.
Introduction: subtalar dislocations, typical of high-energy trauma, are classified as medial, lateral, anterior or posterior depending on the deviation of the foot in relation to the talus. Lateral dislocation accounts for 17% of the total and has a worse prognosis. Immediate reduction is required to reduce the risk of sequelae, the incidence of which is around 90%.
View Article and Find Full Text PDFCancer Lett
September 2025
Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine, Nanjing Medical University, Huaian, 223300, Jiangsu Province, China; Key Laboratory of Autoimmune Diseases of Huaian City, Huaian, 223300, Jiangsu Pr
CAR-T cell therapy, as a representative technology in cancer immunotherapy, has demonstrated notable success in the treatment of hematologic malignancies; however, a significant proportion of patients fail to achieve sustained remission. Through the analysis of bone marrow sequencing data prior to CD19 CAR-T cell therapy, we identified cellular adhesion as a pivotal factor influencing clinical outcomes. We developed a model to predict B-ALL treatment efficacy based on the core genes associated with cellular adhesion, which was validated in our clinical cohort.
View Article and Find Full Text PDFBiomater Adv
September 2025
Graduate School of Medical and Dental Science, Institute of Science Tokyo, 15-45 Yushima, Bunkyo, Tokyo, 113-8510, Japan; Advanced Central Research Organization, Teikyo University, 2-11-1, Kaga, Itabashi, Tokyo, 173-8605, Japan.
This review concentrates on the electroactive ceramic biointerfaces inspired by bone piezoelectricity for advanced ceramic biomaterials. Bone generates electrical potentials through the piezoelectric properties of collagen fibrils and apatite minerals under mechanical loading. These electrical signals influence osteoconductivity and regenerative capacity by osteogenic cells.
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