Microwave-Responsive Engineered Platelet Microneedle Patch for Deep Tumor Penetration and Precision Therapy.

Controllable and precise delivery of therapeutic agents is critical for effective tumor therapy. However, tumor targeting and the deep penetration of drugs remain among the most challenging issues in achieving controlled delivery. Herein, a novel engineered platelet microneedle patch with a microwave-responsive magnetic biometal-organic framework is proposed to facilitate the combination of the engineered platelet and microwave hyperthermia, enhancing deep drug penetration into tumors and enabling precision therapy. The prepared magnetic biometal-organic framework as nanomedicine exhibits excellent microwave thermal effects. The engineered platelets could be activated in the tumor microenvironment to release PMPs and nanomedicines combined with microwave hyperthermia for enhancing both cell uptake and deep drug penetration into tumors. The developed separable microneedle patch system allows the microneedle tip to be quickly detached from the backing layer and retained within the target tissue for repeated local cancer hyperthermia treatments. By integration of engineered platelets into the microneedle patch, the transdermal deep delivery of drugs could be effectively enhanced for local microwave thermochemotherapy of tumors. This work represents the first attempt to graft microwave-responsive inorganic nanomedicines onto platelets as cell drugs, offering a novel strategy for precise drug delivery activated by microwave thermal therapy.