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http://dx.doi.org/10.1186/s12866-025-03787-x | DOI Listing |
Front Cell Infect Microbiol
August 2025
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
[This corrects the article DOI: 10.3389/fcimb.2025.
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September 2025
İstanbul University Faculty of Pharmacy, Department of Pharmaceutical Chemistry, İstanbul, Türkiye.
Objectives: This study focused on synthesizing and characterizing novel thiosemicarbazide derivatives containing a 1,2,4-triazole moiety and evaluating their antimicrobial activity against several bacterial strains. The research aimed to identify key structural features that enhance antimicrobial efficacy through structure-activity relationship analysis and identify the minimum inhibitory concentration (MIC) of the most potent compounds to assess their potential for further development as antimicrobial agents.
Materials And Methods: Nine novel thiosemicarbazide derivatives containing a 1,2,4-triazole moiety were synthesized by reacting 1,2,4-triazole derivatives with thiosemicarbazide precursors, and the products were characterized using infrared spectroscopy, proton nuclear magnetic resonance (H-NMR), carbon-13 nuclear magnetic resonance (C-NMR) spectroscopy, and elemental analysis.
Klin Mikrobiol Infekc Lek
June 2025
Clinic of Infectious Diseases, Central Military Hospital, Prague, Czech Republic, e-mail:
Objective: To evaluate the quality of care provided to patients with febrile neutropenia (FN) hospitalized at the Depart-ment of Infectious Diseases, Military University Hospital Prague, as a foundation for improving the management of this condition.
Material And Methods: A retrospective observational analysis of patients diagnosed with the ICD-10 code D70 from 1 January 2015 to 1 June 2023. All evaluated parameters were selected primarily to facilitate the assessment of care quality and compliance with recommended practices.
Ophthalmology
September 2025
Francis I. Proctor Foundation, University of California San Francisco, USA; UCSF Department of Ophthalmology, University of California, San Francisco, USA; Byers Eye Institute, Stanford University, Palo Alto, USA. Electronic address:
Objective: To determine the effect of adjunctive rose-bengal photodynamic therapy (RB-PDT) in the treatment of fungal, Acanthamoeba, and smear/culture negative infectious keratitis.
Study Design: This international, randomized, double-masked, sham controlled clinical trial, randomizes patients with corneal ulcers in a 1:1 fashion to one of two treatment arms: 1) Topical antimicrobial plus sham RB-PDT or 2) Topical antimicrobial plus RB-PDT.
Main Outcome Measures: The primary outcome was best spectacle-corrected visual acuity (BSCVA) at 6 months.
Liver Int
October 2025
Department of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany.
Background And Aims: Large language models (LLMs) can potentially support clinicians in their daily routine by providing easy access to information. Yet, they are plagued by stating incorrect facts and hallucinating when queried. Increasing the context by providing external databases while prompting LLMs may decrease the risk of misinformation.
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