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Objective: Adults living with progressive or complex conditions experience functional impairments that can impact activities and participation. Assistive technology (AT) is one intervention demonstrated to optimise functioning and reduce disability experienced. This study aimed to identify and characterise international evidence-based clinical practice guidelines (CPGs) which included recommendations on AT interventions for adults with progressive or complex conditions.
Methods: A published review protocol guided searches of four electronic databases and 11 CPG portals. CPGs published between January 2012 and September 2023 in English for adults with progressive or complex conditions were included. Recommendations were catalogued according to: author, year and country of publication; grading of recommendations made; number of recommendations made overall and number pertaining to AT; target condition and/or population; age group/s recommendations related to (if specified); type of AT (categorised into "cognition", "communication", "vision", "hearing", "self-care", "mobility", "combination" or "other"); target professions to apply recommendations; evidence grading; and reference to supporting evidence. AT-related recommendations were summarised narratively. Analysis of the 18 CPGs that met inclusion criteria demonstrated that only 163 (7%) of the total 2,197 recommendations identified pertained to AT. Vocabulary used to describe AT, and detail offered regarding AT interventions was varied impacting the value of some AT-related CPGs.
Impact: This is the first review internationally to identify and document CPG recommendations for adults with progressive or complex conditions, specific to AT interventions. Guidance on types of assistive products - and personnel required for provision - was limited. Further evidence is required to guide practice.
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http://dx.doi.org/10.1080/17483107.2025.2449993 | DOI Listing |
Clin J Am Soc Nephrol
September 2025
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland USA.
Socioeconomic, environmental and lifestyle factors shape kidney health. Among the social determinants of health, access to healthy foods is particularly significant. As a basic need, food is integral to an individual's identity, culture, and health.
View Article and Find Full Text PDFClin J Am Soc Nephrol
September 2025
Kidney Division, Peking University First Hospital, Peking University Institute of Nephrology; Key Laboratory of Kidney Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, China.
Background: The Therapeutic Effects of Steroids in IgA Nephropathy Global (TESTING) trial demonstrated that glucocorticoid therapy reduced proteinuria and improved kidney outcomes in patients with Immunoglobulin A Nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) plays a central role in IgAN pathogenesis by promoting immune complex formation. However, the effects of glucocorticoid on pathogenic IgA levels remain unclear.
View Article and Find Full Text PDFCell Biochem Biophys
September 2025
Medical Biotechnology Research Center, School of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran.
In cardiovascular research, melatonin has shown promise in exhibiting antifibrotic properties and modulating endoplasmic reticulum (ER) stress. However, the exact mechanism by which it influences myocardial fibrosis has not been fully clarified. Therefore, this research aimed to investigate the inhibitory effect of melatonin on the progression of myocardial fibrosis through a mechanism involving the BIP/PERK/CHOP signaling pathway, both in silico and in vivo experimental models.
View Article and Find Full Text PDFNanomicro Lett
September 2025
Department of Mechanical, Aerospace & Biomedical Engineering, University of Tennessee, Knoxville, Knoxville, TN, 37996, USA.
3D printing, as a versatile additive manufacturing technique, offers high design flexibility, rapid prototyping, minimal material waste, and the capability to fabricate complex, customized geometries. These attributes make it particularly well-suited for low-temperature hydrogen electrochemical conversion devices-specifically, proton exchange membrane fuel cells, proton exchange membrane electrolyzer cells, anion exchange membrane electrolyzer cells, and alkaline electrolyzers-which demand finely structured components such as catalyst layers, gas diffusion layers, electrodes, porous transport layers, and bipolar plates. This review provides a focused and critical summary of the current progress in applying 3D printing technologies to these key components.
View Article and Find Full Text PDFIn Vitro Cell Dev Biol Anim
September 2025
Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan.
S100 protein family members S100A8 and S100A9 function primarily as a heterodimer complex (S100A8/A9) in vivo. This complex has been implicated in various cancers, including gastric cancer (GC). Recent studies suggest that these proteins play significant roles in tumor progression, inflammation, and metastasis.
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