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In the modern healthcare system, the rational allocation of emergency department (ED) resources is crucial for enhancing emergency response efficiency, ensuring patient safety, and improving the quality of medical services. This paper focuses on the issue of ED resource allocation and designs a priority sorting system for ED patients. The system classifies patients into two queues: urgent and routine. Considering different service rates, a multi-server preemptive priority queueing model [Formula: see text] and a multi-server non-preemptive priority queueing model [Formula: see text] are constructed. Additionally, the number of beds, K, is introduced as the capacity of the urgent queue. By comprehensively considering the costs associated with patient waiting time, the cost of rejecting the most critical patients, and the total costs of beds and servers, a mixed-integer programming model was constructed with the objective of minimizing the total cost. The particle swarm optimization algorithm was applied to determine the optimal number of servers, service rate, and number of beds. Compared with the model proposed by Alipour-Vaezi et al., our model significantly improves patient waiting times and queue lengths using the same data set: the waiting time [Formula: see text] decreased by 74.44%, [Formula: see text] by 5.79%, and [Formula: see text] by 1.13%; the queue length [Formula: see text] decreased by 78% and [Formula: see text] by 3.33%. Our model effectively reduces patient waiting times and queue lengths while controlling costs, identifies the optimal number of beds, and achieves optimized resource allocation. Finally, we conducted a sensitivity analysis and provided some valuable management insights.
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http://dx.doi.org/10.1038/s41598-025-86158-w | DOI Listing |
Am J Chin Med
September 2025
Department of Pharmacology.
Notoginsenoside R1 (NGR1), a natural triterpenoid saponin, is extracted from , and has cardiovascular and cerebrovascular protective effects due to anti-inflammatory, anti-oxidant, and anti-apoptotic properties. Previous research has suggested a protective role for NGR1 in myocardial ischemia/reperfusion (MI/R) injury. However, the potential mechanisms involved have not been fully elucidated.
View Article and Find Full Text PDFJ R Soc Interface
September 2025
UK Centre for Ecology & Hydrology, Wallingford, Oxfordshire, UK.
Severe fever with thrombocytopaenia syndrome virus (SFTSV) was identified by the World Health Organization as a priority pathogen due to its high case-fatality rate in humans and rapid spread. It is maintained in nature through three transmission pathways: systemic, non-systemic and transovarial. Understanding the relative contributions of these transmission pathways is crucial for developing evidence-informed public health interventions to reduce its spillover risks to humans.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Mathematics, Faculty of Science and Information Technology, Jadara University, Irbid, Jordan.
This study introduces the Wrapped Epanechnikov Exponential Distribution (WEED), a novel circular distribution derived from the Epanechnikov exponential distribution. The probability density function and cumulative distribution function are presented, together with a comprehensive analysis of its properties and parameters, including the characteristic function and trigonometric moments. Parameters are estimated using maximum likelihood estimation (MLE).
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712.
Many soft, tough materials have emerged in recent years, paving the way for advances in wearable electronics, soft robotics, and flexible displays. However, understanding the interfacial fracture behavior of these materials remains a significant challenge, owing to the difficulty of quantifying the respective contributions from viscoelasticity and damage to energy dissipation ahead of cracks. This work aims to address this challenge by labeling a series of polymer networks with fluorogenic mechanophores, subjecting them to T-peel tests at various rates and temperatures, and quantifying their force-induced damage using a confocal microscope.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Bioengineering, Stanford University, Stanford, CA 94305.
Despite periods of permanent darkness and extensive ice coverage in polar environments, photosynthetic ice diatoms display a remarkable capability of living inside the ice matrix. How these organisms navigate such hostile conditions with limited light and extreme cold remains unknown. Using a custom subzero temperature microscope during an Arctic expedition, we present the finding of motility at record-low temperatures in a Eukaryotic cell.
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