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Purpose: Early onset scoliosis (EOS) has traditionally been an indication for MRI because of its association with neural axis abnormalities (NAAs). Because these abnormalities are often clinically silent and concerns regarding sedation in young children are growing, routine MRI for EOS is debated. This study investigates the current practices of EOS MRI screening among surgeons in the Pediatric Spine Study Group (PSSG).
Methods: A survey assessing EOS MRI practices was distributed to the PSSG. The survey presented scenarios that varied in age, curve size, and diagnosis and asked which scenarios would indicate an MRI. Respondents also ranked age, curve progression, etiology, and need for sedation by level of importance when considering to order MRI.
Results: Age and curve progression were ranked as the most important factors when deciding to order MRI. For all non-congenital scoliosis, increased age and curve size were associated with increased rates of MRI among respondents. For idiopathic EOS, more than 60% of respondents would order MRI for patients with curve magnitudes of 45° regardless of age. All respondents would order MRI for congenital EOS before surgery and for EOS caused by neurofibromatosis. For EOS secondary to cerebral palsy, 61% of respondents would order an MRI, and 34% believe that EOS and Prader-Willi syndrome require MRI.
Conclusion: Our results indicate that the MRI screening practices for EOS vary greatly between physicians, as expected. Future research on the prevalence of NAAs in EOS and the clinical outcomes of routine MRI is needed to inform which MRI practices should be standard.
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http://dx.doi.org/10.1007/s43390-024-01033-4 | DOI Listing |
Odontology
September 2025
Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.
This study aimed to investigate the age-related alterations in mesial roots of mandibular first molar in terms of root canal curvature values, dentin thickness, interorifice distance, deviation from apical foramen, and location of apical foramen using a three-dimensional curvature measurement method and micro-computed tomography (micro-CT). Forty-five mesial roots of mandibular first molars from three age groups (Group 1: ≤ 30 years, Group 2: 31-59 years, Group 3: ≥ 60 years) were scanned using micro-CT. The central axis of each mesiobuccal and mesiolingual canal was analyzed using cubic B-spline curves to calculate canal curvature.
View Article and Find Full Text PDFAnn Hematol
September 2025
Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
To evaluate whether age modifies the association between the geriatric nutritional risk index (GNRI) and overall survival (OS) in patients aged ≥ 18 years with newly diagnosed diffuse large B-cell lymphoma (DLBCL), we conducted a multi-centre retrospective study of 552 patients. Multivariable Cox regression with restricted cubic spline (RCS) modelling showed that GNRI was significantly associated with OS, but the relationship was non-linear (P for non-linearity = 0.0158).
View Article and Find Full Text PDFMinerva Dent Oral Sci
September 2025
Division of Implant Prosthodontics, Department of Surgical Sciences, University of Genoa, Genoa, Italy.
Background: The purpose of the study is to evaluate the use of a magnetodynamic instrument (Magnetic Mallet, Metaergonomica, Turbigo, Milan, Italy) to perform a horizontal bone expansion in edentulous sites that need to be rehabilitated with a dental implant.
Methods: A sample of 15 patients, 11 men and 4 women, age between 39 and 78 years, was analyzed. A total of 18 conical-shaped implants with a diameter of 3.
Background: The goal was to explore the impact of the NR1D1 gene on the occurrence, development, and prognosis of colorectal cancer (CRC) using bioinformatics approaches.
Methods: CRC transcriptomic and clinical data from TCGA were analyzed to compare NR1D1 expression in tumors and various clinical stages. Survival differences between high and low NR1D1 expression groups were assessed using the R survival package.
Pediatr Pulmonol
September 2025
Perinatal Institute, Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Objective: To wean respiratory support, preterm infants with severe respiratory failure are often administered systemic corticosteroids. We sought to evaluate if postnatal age or clinical characteristics predicted death or tracheostomy following systemic dexamethasone in evolving bronchopulmonary dysplasia.
Study Design: We performed a retrospective study of infants born at ≤ 30 weeks' gestational age cared for at a Level IV referral center from 2009 to 2019 who received a complete course of systemic dexamethasone beyond 4 weeks of age for the indication of preventing death and/or liberating from positive pressure ventilation.