Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: As multiple Japanese academic societies have recently issued treatment guidelines for perinatal antidepressant treatments, it is considered worthwhile to evaluate the latest trends and continuation of antidepressant medication during pregnancy to optimize antenatal prescriptions.
Methods: The prevalence, trend, and continuation of antidepressant use during pregnancy in Japan from 2012 to 2023 were evaluated, using a large administrative claims database, in women whose pregnancies ended in live births. Annual changes were evaluated using a multivariate logistic regression model adjusted for maternal age at delivery.
Results: Of 179,797 women with a mean maternal age at delivery of 32.5 years, 1870 (1.04%) were prescribed antidepressants during pregnancy. The prevalence significantly increased (P < 0.0001) from 0.63% in 2012 to 1.67% in 2023. Antidepressants were prescribed to 1730 women (0.96%) during the first trimester. Of these, 670 (38.7%) were antidepressant continuers throughout pregnancy, showing a significant increase (P < 0.0001) from 19.51% in 2012 to 50.70% in 2023. The most frequently prescribed class of antidepressants during pregnancy was serotonin reuptake inhibitors (0.74%), especially sertraline (0.33%) and escitalopram (0.23%), with a significant increase in their annual prevalence.
Limitations: Prescriptions for women whose pregnancies ended in abortion or stillbirth could not be evaluated.
Conclusions: Given that antidepressant use and its continuation during pregnancy have become more common, it is important to further disseminate knowledge of the guidelines to healthcare professionals and women of childbearing age, including the promotion of preconception care and shared decision-making.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jad.2025.01.044 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Design, Synthesis, and Biological Evaluation of 8-Phenyl-THIQ as Antidepressive Agents.
Drug Dev Res
September 2025
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, P. R. China.
The structural modification and derivatization of natural products represent an essential pathway for pharmaceutical innovation in the management of depression. The 8-phenyl tetrahydroisoquinoline, as a parent core, was obtained from magnoflorine by a structural simplification strategy. The present report details the synthesis and antidepressant activity studies of 8-phenyl-THIQ analogs.
View Article and Find Full Text PDFA Case Series of Young People Receiving Adjunctive Immunotherapy for Neuroimmune-Mediated Major Mood or Psychotic Syndromes.
Biol Psychiatry Glob Open Sci
November 2025
Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Background: Neuroimmune processes are often implicated in young people with atypical neuropsychiatric disorders, yet treatment implications remain controversial. This case series details young people with primary psychiatric disorders who received adjunctive immunotherapy after thorough investigation and extensive conventional treatments.
Methods: We evaluated 45 individuals (93% female, ages 12-30 years) with atypical psychiatric presentations suggesting potential neuroimmune involvement.
Vortioxetine Improves Brain Glymphatic System Function, Functional Connectivity, and Cognitive Functions in Major Depressive Disorder.
Depress Anxiety
September 2025
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
The therapeutic effects of vortioxetine on mood and cognition have been documented in major depressive disorder (MDD). This study aims to examine whether vortioxetine can improve brain glymphatic system function and connections among functional brain networks and to explore the underlying relationships among these changes. A total of 34 patients with MDD and 41 healthy controls (HCs) were recruited in the study.
View Article and Find Full Text PDFGender Differences in Psychotropic Medication Use: A Naturalistic Study Among Psychiatric Outpatients in Secondary Care.
J Clin Psychopharmacol
September 2025
Department of Psychiatry, Rob Giel Research Center, University of Groningen, University Medical Center Groningen.
Purpose/background: Previous studies among psychiatric patients have shown differences between men and women in psychotropic medication prescription patterns. The factors underlying these differences are still poorly understood. This exploratory study aimed to investigate a range of clinical and demographic factors in their contributions to explaining these gender differences.
View Article and Find Full Text PDFMolecular characterization of Spodoptera frugiperda nose resistant to fluoxetine protein 6 and its putative involvement in tolerance to cyantraniliprole.
Pestic Biochem Physiol
November 2025
College of Plant Protection, Yangzhou University, Yangzhou 225009, China; Jiangsu Province Engineering Research Center of Green Pesticides, Yangzhou University, Yangzhou 225009, China. Electronic address:
Spodoptera frugiperda (FAW) is a notorious polyphagous pest that has developed resistance to various insecticides including diamide insecticides. Our previous study established a FAW cyantraniliprole-resistant (SfCYAN-R) strain by laboratory resistance selection of susceptible strain (SfCYAN-S), however, the potential resistance mechanisms of FAW to cyantraniliprole remain unclear. In this study, SfNrf6 encoding nose resistant to fluoxetine (Nrf) protein 6 was identified to be upregulated in SfCYAN-R strain compared with SfCYAN-S strain based on RNA-Seq data and RT-qPCR.
View Article and Find Full Text PDF