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http://dx.doi.org/10.12965/jer.2448666.333 | DOI Listing |
Medicine (Baltimore)
September 2025
Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
Sarcopenia, a growing public health concern lacking targeted therapies, highlights the need to investigate modifiable factors like physical activity (PA) and sedentary behavior, which influence muscle health. However, most research focuses on older adults, with limited data on young and middle-aged populations. This study leverages the National Health and Nutrition Examination Survey (NHANES) data to investigate this topic in the US population aged 18 to 59 to address this critical gap.
View Article and Find Full Text PDFFront Public Health
September 2025
Changzhou University, Changzhou, Jiangsu, China.
Objective: Insulin-like growth factor-1 (IGF-1) is thought to play an important role in regulating skeletal muscle mass and function, with its decline potentially linked to age-related frailty and sarcopenia. Given the limitations of pharmacological and nutritional interventions, exercise may serve as a potential non-pharmacological strategy to modulate IGF-1 levels. The purpose of this study is to systematically evaluates the effects of exercise interventions on serum IGF-1 levels in older adults with frailty and/or sarcopenia using a meta-analysis approach.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China.
Multimorbidity of chronic diseases is one of the most common health issues among older adults, and the resulting demand for long-term medical care and management imposes a considerable burden on healthcare systems. Muscle strength, a core indicator of overall health status, is closely associated with the risk of developing multimorbidity of chronic diseases in older adults. Decline in muscle strength not only increases the risk of multimorbidity of chronic diseases but also interacts with it to exacerbate disease burden.
View Article and Find Full Text PDFJ Physiol
September 2025
Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, USA.
Cognitive decline and physical impairment are often linked with ageing, contributing to declines in health span and loss of independence in older adults. Pathological cognitive decline with age is largely considered to be a brain-centric challenge. However, recent findings have begun to challenge this paradigm as the health of peripheral systems, namely skeletal muscle, predict cognitive decline associated with Alzheimer's disease (AD).
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Nephrology, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China.
Background And Aims: Sarcopenia, characterized by age-related loss of muscle mass and function, increases adverse outcomes in older adults. The predicted skeletal muscle mass index (pSMI), derived from serum creatinine and cystatin C, may serve as a practical biomarker. This study evaluated pSMI's ability to predict sarcopenia and mortality in older Chinese adults.
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