Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Yakutia is one of the coldest permanently inhabited regions in the world, characterized by a subarctic climate with average January temperatures near -40 °C and the minimum below -60 °C. Recently, we demonstrated accelerated epigenetic aging of the Yakutian population in comparison to their Central Russian counterparts, residing in a considerably milder climate. In this paper, we analyzed these cohorts from the inflammaging perspective and addressed two hypotheses: a mismatch in the immunological profiles and accelerated inflammatory aging in Yakuts. We found that the levels of 17 cytokines displayed statistically significant differences in the mean values between the groups (with minimal -value = 2.06 × 10), and 6 of them are among 10 SImAge markers. We demonstrated that five out of these six markers (PDGFB, CD40LG, VEGFA, PDGFA, and CXCL10) had higher mean levels in the Yakutian cohort, and therefore, due to their positive chronological age correlation, might indicate a trend toward accelerated inflammatory aging. At the same time, a statistically significant biological age acceleration difference between the two cohorts according to the inflammatory SImAge clock was not detected because they had similar levels of CXCL9, CCL22, and IL6, the top contributing biomarkers to SImAge. We introduced an explainable deep neural network to separate individual inflammatory profiles between the two groups, resulting in over 95% accuracy. The obtained results allow for hypothesizing the specificity of cytokine and chemokine profiles among people living in extremely cold climates, possibly reflecting the effects of long-term human (dis)adaptation to cold conditions related to inflammaging and the risk of developing a number of pathologies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679676 | PMC |
| http://dx.doi.org/10.3390/ijms252413741 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Metabolomic profiling reveals that the heterogeneity of microhabitats can assist intertidal mollusks in surviving extreme cold events.
Mar Life Sci Technol
August 2025
Key Laboratory of Mariculture of Ministry of Education, Fisheries College, Ocean University of China, Qingdao, 266003 China.
Unlabelled: Microhabitat heterogeneity results in significant variations in the thermal environment on a small spatial scale, leading to different intensities of cold stress during extreme low-temperature events. Investigating variations in body temperature and metabolomic responses of organisms inhabiting different microhabitats emerges as an important task for understanding how organisms respond to more frequent extreme low-temperature events in the face of climate change. In the present study, we measured substrate temperature, air temperature, wind speed, light intensity, and body temperature to evaluate the relative importance of drivers that affect body temperature in different microhabitats, and determined the metabolomic responses of intertidal snails and limpets from different microhabitats (snail: exposed vs.
View Article and Find Full Text PDFComparative genomic insights into adaptation, selection signatures, and population dynamics in indigenous Indian sheep and foreign breeds.
Front Genet
August 2025
College of Poultry Production and Management, TANUVAS, Hosur, India.
Background: India's indigenous sheep breeds have evolved under extreme and diverse agro-ecological pressures, yet the genomic basis of their resilience and local adaptation remains poorly understood.
Method: This study combines genomic inbreeding estimates, runs of homozygosity (ROH), population structure analyses, and composite selection scans to investigate three native Indian breeds-Changthangi, Deccani, and Garole-within a panel of nine breeds that also includes populations from Africa (Ethiopian Menz), East and South Asia (Tibetan, Chinese Merino, Bangladesh Garole, Bangladesh East), and Europe (Suffolk).
Results: ROH and heterozygosity estimates revealed strong contrasts: Bangladesh East sheep exhibited high genomic inbreeding (F≈14.
The role of mobility and air-conditioning in prenatal temperature exposure and birth outcomes: A prospective birth cohort study in Guangzhou.
Environ Res
September 2025
School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:
Climate change has heightened awareness of the health impacts of non-optimal temperatures (cold and heat), including the effect of gestational exposure and birth outcomes. However, temperature exposure assessment remains methodologically challenging due to unaccounted individual spatiotemporal mobility and adaptive behaviors, a gap that has not been adequately addressed in published studies. Using data from a prospective birth cohort in Guangzhou, China, conducted from 2017 to 2020, we assessed and compared three different exposure measures: home-based exposure, derived solely from ambient temperature data at residential locations; mobility-based exposure, incorporating individuals' spatiotemporal activities to capture dynamic environmental conditions; and AC & mobility-based exposure, an extension of the mobility-based approach that further integrates data on air-conditioning usage.
View Article and Find Full Text PDFAssessing cold exposure risk during cold waves in Beijing using high spatiotemporal resolution population data and temperature variations.
Environ Int
September 2025
State Key Laboratory of Severe Weather (LASW), Chinese Academy of Meteorological Sciences (CAMS), China Meteorological Administration, Beijing 100081, China.
In the context of global warming, the frequency and intensity of extreme weather events are intensifying. Although cold waves have significant impacts on human health, related research remains insufficient. This study integrates high-resolution population dynamics and temperature data to assess cold exposure risks during cold waves in Beijing, addressing a critical research gap in urban public health.
View Article and Find Full Text PDFArctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance.
J Fish Biol
September 2025
Department of Biological Sciences, University of New Brunswick - Saint John, Saint John, New Brunswick, Canada.
Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to which they seasonally adjust cardiac thermal performance and adrenergic control. We assessed the intrinsic and maximum heart rate (f and f) of anaesthetised fish through cholinergic blockade and either adrenergic blockade (f) or stimulation (f) during acute warming.
View Article and Find Full Text PDF