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Objective: To evaluate factors impacting access to and timing of surgery in patients with submucous cleft palate (SMCP) and velopharyngeal dysfunction (VPD).
Study Design: Retrospective cohort study.
Setting: Single academic medical center.
Methods: Patients with SMCP and VPD between 2004 and 2021 were identified. Variables included national and state area deprivation index (ADI) percentiles, child opportunity index (COI) categories, distance to care, and insurance status. χ, Fisher's exact test, Wilcoxon rank-sum, Spearman rank correlation, t test, and linear regression (α = .05) were used to investigate the relationships between these variables and surgical status and timing.
Results: A total of 168 patients were included, 94 surgical and 74 nonsurgical. Patients were predominantly white (160/168; 95.2%), Male (103/168; 61.3%), and non-Hispanic (153/168; 91.1%). There were no intergroup differences with respect to ADI, COI, insurance status, or distance from the hospital. Surgical patients were more likely to have overt SMCP (P = .03), earlier age at SMCP diagnosis (P = .02), and higher baseline Pittsburgh weighted speech score (PWSS) (P = <.001). In multivariable regression, younger age at surgery was found to be significantly associated with higher baseline PWSS (P = .001) and lower state ADI deciles (P = .03). Patients with private insurance had a lower baseline PWSS than those with public insurance (P = .04). Insurance status was not significantly associated with age at diagnosis (P = .79) or age at surgery (P = .08).
Conclusion: In this study, patients from less disadvantaged neighborhoods were found to have earlier surgical intervention, highlighting the importance of incorporating social determinants of health in the evaluation of VPD and SMCP patients to prevent treatment delays.
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http://dx.doi.org/10.1002/ohn.1111 | DOI Listing |
J Clin Ultrasound
September 2025
Clinic of Obstetrics and Gynecology, Sakarya Education and Research Hospital, Sakarya, Turkiye.
Hysteroscopic resection is considered the gold standard treatment for the removal of submucous uterine leiomyoma (SMLs). However, when hysteroscopic equipment is unavailable, alternative treatment approaches must be explored. In this case report, we present a video demonstrating the transcervical resection of an SML performed under transabdominal ultrasonography guidance on a patient with persistent abnormal uterine bleeding.
View Article and Find Full Text PDFBr J Oral Maxillofac Surg
August 2025
Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077 Tamil Nadu, India. Electronic address:
Oral submucous fibrosis (OSMF) is a potentially malignant disorder with a risk of progressing to oral squamous cell carcinoma. A key indicator of malignant transformation is increased and uncontrolled cell proliferation, which can be evaluated using markers such as Ki67. This study aimed to assess Ki67 expression in OSMF, compare its levels across different associated habits, and correlate expression with clinical and histological grading.
View Article and Find Full Text PDFDent J (Basel)
August 2025
College of Dentistry, University of Saskatchewan, 105 Wiggins Road, Saskatoon, SK S7N 5E4, Canada.
The areca nut (AN) is chewed by approximately 600 million people worldwide. Among AN chewers, ~5% develop oral submucosal fibrosis (OSF), a progressive fibrotic disorder of the oral cavity. OSF is characterized by subepithelial fibrosis and mucosal rigidity, leading to restricted mouth opening, difficulty in mastication, deglutition, and speech.
View Article and Find Full Text PDFOral submucous fibrosis (OSF) is a chronic and progressive fibrosis disease. Although its pathological stages are well characterized in clinical settings, corresponding animal models remain lacking, which has significantly hindered in-depth mechanistic studies and the development of targeted interventions. Herein, we developed new methods in creating OSF models in rats and mice by different injection frequency of bleomycin (BLM) to simulate early and middle stages of fibrosis.
View Article and Find Full Text PDFBioinformation
May 2025
Department of Oral Medicine and Radiology, Guru Nanakdev Dental College and Research Institute, Sunam, Punjab, India.
One of the potentially malignant disorders of the oral mucosa in Asian nations is known as oral submucous fibrosis (OSMF). The drug, surgical and combination therapies are some of the several OSMF treatment options. The importance of colchicine in the treatment of oral submucous fibrosis is still unclear.
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