Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
(Mill.) Druce is rich in bioactive components with high medicinal value. To maximize the clinical benefits, it is of great significance to efficiently extract key bioactive components from appropriate growth stages in which they are most abundant. In this study, we analyzed the changes of metabolite accumulation and protein expression in rhizomes at different growth stages using targeted metabolomics combined with proteomics, and identified a total of 1,237 differentially abundant metabolites (DAMs). Flavonoids accumulated most in winter, and the biosynthesis pathways associated with flavonoids, isoflavonoids, flavones and flavonols exhibited significant differentially expressed proteins (DEPs). Among them, PGT, FLS, CYP75B1, HIDH, IF7MAT, and UFT73C6 were positively correlated with flavonoid accumulation. Steroid saponins accumulated most in spring, and the biosynthetic pathways of steroid and brassinosteroid biosynthesis exhibited DEPs. Among them, FDFT1, TM7SF2, DHCR7, CAS1, and 3BETAHSDD were positively correlated with steroidal saponin accumulation. In summary, these results revealed the accumulation of secondary metabolites in different growth stages, which can provide an effective reference for the extraction of specific bioactive components and the study of their regulatory mechanisms.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696735 | PMC |
| http://dx.doi.org/10.3389/fpls.2024.1487613 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploration of the Chemical Components and Biological Activities of Hippophae salicifolia Extracts: In Vitro, Molecular Docking, and MD Simulation Approaches.
Chem Biodivers
September 2025
Department of Biology, Faculty of Science, Selçuk University, Konya, Turkey.
Hippophae salicifolia, commonly known as sea buckthorn, is native to the Indian Himalayan region. This study is the first to comprehensively assess the phytochemical profile and biological activities of H. salicifolia leaves extracted through maceration, infusion, and percolation (Soxhlet apparatus) methods.
View Article and Find Full Text PDFFrom chemical to mechanism-driven quality control of : spectrum effect - chemometrics-pharmacology integration decoding antioxidant-anti-inflammatory crosstalk.
Anal Methods
September 2025
Department of Pharmacy, Kunshan Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, 215332, China.
(GR) is primarily produced in Laiyang and Chifeng. It is a functional food with therapeutic and health-promoting effects due to its antioxidant and anti-inflammatory properties. However, the current standards only stipulate authentication criteria, without establishing a comprehensive evaluation framework to systematically enhance the quality control of GR.
View Article and Find Full Text PDFEffect of Environment- and Animal-Based Factors on the Main Components and Bioactive Substances in Buffalo Colostrum and Calf Serum.
Anim Sci J
September 2025
Department of Animal Science, Faculty of Agriculture, Ondokuz Mayis University, Atakum, Samsun, Türkiye.
This study aimed to evaluate the effect of some environment- and animal-based factors, such as body condition score (BCS) on 15-20 days before parturition, parity, and calving season on colostrum dry matter (DM), fat, solids-nonfat (SNF), protein, and lactose contents as well as colostrum and calf's serum immunoglobulin (IgG, IgA, and IgM), IGF-1, and lactoferrin concentrations in buffaloes. Therefore, the components of colostrum (at the first milking) and calf serum samples (at 24-48 h and 28 days after birth) from 86 Anatolian buffalo cows were analyzed by an infrared milk analyzer and ELISA test. The high BCS enhanced colostrum DM, fat, and IgG content; calf serum IgG concentration at 24-48 h, and lactoferrin at 28 days compared to low BCS.
View Article and Find Full Text PDFMolecular mechanisms of the Suting Pill in the treatment of asthma: A study based on network pharmacology and molecular docking.
Medicine (Baltimore)
September 2025
Department of Pharmacy, The Third Department, Air Force Special Service Sanatorium, Hangzhou, Zhejiang, China.
Background: Asthma is a chronic respiratory disease characterized by complex etiology and marked heterogeneity. It is one of the most prevalent chronic airway conditions in children, with increasing prevalence in recent years. The Suting Pill (STP), a traditional Chinese medicine for childhood asthma, has an unclear mechanism.
View Article and Find Full Text PDFInvestigating the mechanism of gastrodin-regulated miR-128-3p in methamphetamine dependence via integrated pharmacology.
Medicine (Baltimore)
September 2025
Department of Pharmacology of Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Gastrodin (GAS), the principal bioactive component derived from Gastrodia elata Bl., has demonstrated efficacy in attenuating methamphetamine (MA) induced conditioned place preference (CPP) in animal models. However, the molecular mechanisms underlying its anti-addictive effects, particularly the role of miRNAs, remain insufficiently understood.
View Article and Find Full Text PDF