Exploration of the Chemical Components and Biological Activities of Hippophae salicifolia Extracts: In Vitro, Molecular Docking, and MD Simulation Approaches.

Hippophae salicifolia, commonly known as sea buckthorn, is native to the Indian Himalayan region. This study is the first to comprehensively assess the phytochemical profile and biological activities of H. salicifolia leaves extracted through maceration, infusion, and percolation (Soxhlet apparatus) methods.

Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.

In general, endodontic infections are polymicrobial infections, and the severity of the infection depends on the pathogenicity of the microbes and the resistance of the host. For the treatment of endodontic infections, antibiotics are widely used; however, the development of resistance raises concerns for their wide-scale application; hence, there is always an unmet need to develop alternative treatment strategies in the fight against endodontic infection. Basically, the searches were conducted in PubMed (459), Science Direct (559 articles), and WOS (493) using keywords and phrases to identify relevant articles.

Integration of click chemistry and graphene driven molecular design: A mechanistic standpoint on targeted cancer therapeutics.

Cancer therapeutics require a deep understanding of molecular mechanisms and novel drug delivery approaches. Click chemistry, a powerful tool for the rapid and efficient formation of covalent bonds emerged as a cherished technique for designing and synthesizing molecular probes. The present paper explores the potential of click chemistry with graphene modifications for possible cancer therapeutics for the first time.

Exploring the Therapeutic Potential of Vesicular Nanocarrier Systems for Elimination of Skin Cancer.

Background: Skin cancer, a common malignancy worldwide, has increased incidence and mortality. Thus, it is a public health issue and a significant illness burden, which increases treatment costs. Chemotherapy and surgery are used to treat skin cancer.

Advances in VEGFR Inhibitors: A Comprehensive Review of Novel Anticancer Agents.

Cancer, characterized by aberrant cell growth, presents a formidable health challenge, impacting millions of individuals worldwide each year. Among the myriad mechanisms facilitating tumor progression, Vascular Endothelial Growth Factor receptors (VEGFR) play a pivotal role in driving angiogenesis the process by which tumors develop their own blood supply. This vascularization not only supports tumor nourishment and growth but also facilitates metastasis, enabling cancer to spread to distant sites.

Single/ Multiple Dose Percutaneously Injected LR-PRP Enhances Union Rate in Fracture Delayed Unions: A Prospective Case Series.

Background: Average bone healing times of common fractures in adults ranges from 3 to 12 weeks and is location dependent. Platelet Rich Plasma (PRP) stimulates natural healing process through growth factors contained in platelets and has been employed for the same in delayed unions.

Methods: All patients > 18 years and documented delayed union were included in the study.

Retraction Note: Ameliorative potential of against streptozotocin-induced diabetes in rats: biochemical and histopathological studies.

[This retracts the article DOI: 10.1007/s13205-021-02811-x.].

Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds.

Lung cancer is a heterogeneous group of malignancies with high incidence worldwide. It is the most frequently occurring cancer in men and the second most common in women. Due to its frequent diagnosis and variable response to treatment, lung cancer was reported as the top cause of cancer-related deaths worldwide in 2020.

Plant based food bioactives: A boon or bane for neurological disorders.

Neurological disorders are the foremost occurring diseases across the globe resulting in progressive dysfunction, loss of neuronal structure ultimately cell death. Therefore, attention has been drawn toward the natural resources for the search of neuroprotective agents. Plant-based food bioactives have emerged as potential neuroprotective agents for the treatment of neurodegenerative disorders.

Delineating meta-quantitative trait loci for anthracnose resistance in common bean ( L.).

Anthracnose, caused by the fungus , is one of the devastating disease affecting common bean production and productivity worldwide. Several quantitative trait loci (QTLs) for anthracnose resistance have been identified. In order to make use of these QTLs in common bean breeding programs, a detailed meta-QTL (MQTL) analysis has been conducted.

Hypericin and its anticancer effects: From mechanism of action to potential therapeutic application.

Background: Emerging studies indicate that hypericin has diverse pharmacological actions and exhibits potential for treatment of various types of cancer.

Purpose: The current review evaluates the pharmacological activity, associated molecular mechanism, and therapeutic application of hypericin as an anticancer agent according to the most recent state of knowledge with special emphasis on clinical trials and safety profile.

Method: This review follows The Preferred Reporting Items for Systematic Reviews criteria.

Ameliorative potential of against streptozotocin-induced diabetes in rats: biochemical and histopathological studies.

The study aimed to investigate the acute toxicity, antidiabetic potential (in-vitro and in-vivo) of the (L.) Silva Manso at fraction level. The plant was fractionated into different fractions, i.

Allelic Diversity, Structural Analysis, and Genome-Wide Association Study (GWAS) for Yield and Related Traits Using Unexplored Common Bean ( L.) Germplasm From Western Himalayas.

The north-western Indian Himalayas possesses vast diversity in common bean germplasm due to several years of natural adaptation and farmer's selection. Systematic efforts have been made for the first time for the characterization and use of this huge diversity for the identification of genes/quantitative trait loci (QTLs) for yield and yield-contributing traits in common bean in India. A core set of 96 diverse common bean genotypes was characterized using 91 genome-wide genomic and genic simple sequence repeat (SSR) markers.

anthelmintic activity of and prediction of mechanistic role on .

Helminths born diseases are related to pitiable management practices and improper control strategies. The medicinal plants contain various phytoconstituents that are liable for their anthelmintic activity. The aerial parts of the were successively extracted with microwaves assisted extraction using petroleum ether, ethyl acetate, methanol, hydroalcoholic and aqueous solvents to get respective extracts (CAPE, CAEE, CAME, CAHE, and CAAE).

The Possible Role of Saponin in Type-II Diabetes- A Review.

Background: The possible role of secondary metabolites in the management of diabetes is a great concern and constant discussion. This characteristic seems relevant and should be the subject of thorough discussion with respect to saponin.

Objective: The current data mainly focus on the impact of saponin in the treatment of type-II diabetes.

Bilateral Ultrasound-guided Erector Spinae Plane Block for Postoperative Analgesia in Lumbar Spine Surgery: A Randomized Control Trial.

Background: Major lumbar spine surgery causes severe postoperative pain. The primary objective of this randomized controlled study was to compare the effect of ultrasound (US)-guided erector spinae plane (ESP) block on 24-hour postoperative cumulative opioid requirements with standard (opioid-based) analgesia. Postoperative pain control and patient satisfaction were also assessed.

Gene/QTL discovery for Anthracnose in common bean (Phaseolus vulgaris L.) from North-western Himalayas.

Common bean (Phaseolus vulgaris L.) is one of the most important grain legume crops in the world. The beans grown in north-western Himalayas possess huge diversity for seed color, shape and size but are mostly susceptible to Anthracnose disease caused by seed born fungus Colletotrichum lindemuthianum.

Preventive pharmacotherapy in type 2 diabetes mellitus.

Over the last few decades certain demographic changes have been observed worldwide, which have led to an increase in the prevalence of chronic non-communicable diseases. Type 2 diabetes mellitus and associated cardiovascular disease are major contributors to this disease burden leading to rising morbidity and mortality. It is worrisome to see that type 2 diabetes with its micro- and macrovascular complications is occurring in younger populations where it was hitherto unseen.

Antiepileptic potential of flavonoids fraction from the leaves of Anisomeles malabarica.

Ethnopharmacological Relevance: The plant Chodara (Anisomeles malabarica R.Br. Family: Lamiaceae) has numerous therapeutic utilities in folk medicine.